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Pharmacology: Antibiotics > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Aminopenicillin

A

Amoxicillin

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2
Q

Cefazolin use

A

Surgical site infections

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3
Q

Quinupristin-dalfopristin side effects

A
  • hyperbilirubinemia
  • arthralgia
  • phelbitis
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4
Q

Amoxicillin use

A

URI

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5
Q

Macrolides use

A

Respiratory tract infections
Atypical
Peptic ulcer

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6
Q

Inhibit DNA topoisomerase

A

Fluoroquinolones

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7
Q

Aztreonam use

A

Pseudomonas

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8
Q

Drug of choice for CDAD

A

Metro

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9
Q

BBW avoid with MAOIs

A

Linezolid

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10
Q

Side effects of chloramphenicol

A

Gray baby syndrome
Aplastic anemia
BM suppresion

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11
Q

Cipro use

A 
UTIs
Gastroenteris
Antrax
Plague
Influenzae
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12
Q

Tetracycline MOA

A

Bacteriostatic
30S

Inhibit binding tRNA to A —> prevent addition of AA

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13
Q

Vanco use

A

MRSA

CDAD

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14
Q

Anti-staph penicillin

A

Nafcillin

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15
Q

Fidaxomicin use

A

C diff

Alternative to metro and vanco
Lower risk of recurrence

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16
Q

Drugs decreased kidney function

A 
Aminoglycosides
Vanco
Cephalo
SMX/TMP
Penicillin
Carbapenems
Aztreonam
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17
Q

Alternative for metronidazole for CDAD

A

Vanco

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18
Q

Doxycycline use

A

Atypicals
Tick
Peptic ulcer
Malaria

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19
Q

TMP/SMX MOA

A

bactericidal

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20
Q

Quinupristin-dalfopristin use

A

MRSA

VRE

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21
Q

Fosfomycin use

A

UTIs

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22
Q

Inhibit RNA polymerase

A

Fidaxomicin

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23
Q

Doxycycline side effects

A
  • teeth
  • superinfection
  • photosensitive
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24
Q

Respiratory FQ

A

Cipro

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25
Q

Standard penicillin

A

Pen g

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26
Q

SMX MOA

A

Bacteriostatic

Competitive inhibitor of dihydropteroate synthesis

Prevents DNA replication

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27
Q

BBW carcinogenic in animals

A

Metro

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28
Q

Tigecycline BBW

A

Increase all cause mortality

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29
Q

Nitroimdazole MOA

A

Bactericidal
Prodrug

Reduction of nitro group

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30
Q

Side effects of imipenem-cilastatin

A

N/D
Hypersensitivity
Seizures

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31
Q

Bind 30S

A

Aminoglycosides

Tetracyclines

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32
Q

Only cephalosporin active against MRSA

A

Ceftaroline

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33
Q

Fluoroquinolone MOA

A

Inhibit topoisomerases

Bactericidal

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34
Q

Cefepime use

A

Nosocomial

Febrile neutropenia

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35
Q

Linezolid MOA

A

23s RNA of 50S

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36
Q

Imipenem-cilastatin use

A

MSSA

MDR

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37
Q

Clindamycin MOA

A

Bacteriostatic
50S
Block peptide formation

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38
Q

BBW MG

A

Cipro

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39
Q

Biliary sludging

A

Ceftriaxone

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40
Q

Time dependent

A

Cell wall inhibitors
Macrolides
Tetracycline

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41
Q

Chloramphenicol BBW

A

Blood dyscrasias

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42
Q

Aminoglycosides use

A

Endocarditis
Serious G- infections
Tularemia & plague
- UTIs

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43
Q

Which drugs have a prolonged cardiac QT?

A

Macrolides

Fluoroquinolones

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44
Q

SMX side effects

A

Kernicterus
Rash & SJS
Hemolytic anemia (G6PD)

45
Q

Anti-pseudomonal penicillin

A

Piperacillin-tazobactam

46
Q

Tetracyclines

A

Doxycycline

Tigecycline

47
Q

Macrolides

A

Azithromycin

Clarithromycin

48
Q

TMP side effects

A

BM suppression

Hyperkalemia

49
Q

Macrolides MOA

A

Bacteriostatic
50S

Inhibit translocation of protein elongation

50
Q

Which drug is mainly used outside of the US?

A

Chloramphenicol

51
Q

TMP use

A

UTIs

Otitis media

52
Q

Chloramphenicol use

A

Outside of US: MRSA, VRE

US: meningitis

53
Q

Alternative to extended spec penicillin and aminoglycosides

54
Q

Post-antibiotic effect

A

Aminoglycosides

Amikacin/gentamicin

55
Q

Peak concentration dependent

A

Aminoglycosides

Fluoroquinolones

56
Q

1st gen ceph

57
Q

DI metro

A

Ethanol: disulfiram like reaction

58
Q

Drug can’t be taken with dairy

A

Tetracyclines

Fluorquinolones

59
Q

Jarisch Herxheimer

60
Q

4th gen ceph

61
Q

Linezolid side effects

A
  • myelosuppresion
  • neuropathy
  • lactic acidosis
62
Q

Inhibitor of transglycosylation

A

Glycopeptides

63
Q

Ceftaroline use

64
Q

Fosfomycin MOA

A
  • inhibit murein monomers in cytosol
  • glycerophosphate transporter
  • bactericidal
65
Q

Chloramphenicol MOA

A

50S
Inhibit binding tRNA to A

In liver

66
Q

BBW increase all cause mortality

A

Tigecycline

67
Q

Inhibitor of transpeptidation

A

Beta lactam

68
Q

Vanco MOA

A

Block Nam-Nag

69
Q

Metro BBW

A

Carcinogenic in animals

70
Q

DI with doxycyline

A

With Pen G against pneumo meningitis

71
Q

Inhibit folic acid synthesis

A

sulfonamides

Trimethoprim

72
Q

Linezolid BBW

A

Avoid with MOAIs

73
Q

TMP/SMX side effects

A

Well tolerated
HIV S
Same as individual drugs

74
Q

DNA damage

A

Metronidazole

75
Q

Fluoroquinolone

76
Q

Quinupristin-dalfopristin MOA

A

D: 23S RNA of 50S
Q: 50S

Bactericidal

77
Q

Cipro side effects

A

CDAD
Hepatotoxicity
Photosensitive
Hypoglycemia

78
Q

Drugs decreased liver function

A 
Clindamycin
Macrolides
Chloramphenicol
Tetracycline
Metro
79
Q

TMP MOA

A

Bacteriostatic

Prevent reduction of dihydrofolate to form THF

Prevent DNA replication

80
Q

Nafcillin use

81
Q

Non-allergic maculopapular rash

A

Amoxicillin

82
Q

Metronidazole use

A 
CDAD 
Anaerobic 
Bacterial vag
Peptic ulcer
Parasites
83
Q

Aminoglycosides side effects

A

Ototoxicity
Nephrotoxicity
NM blockade

84
Q

3rd gen ceph

A

Ceftriaxone

85
Q

AUC dependent

A

Tetracycline

Vancomycin

86
Q

BBW clindamycin

A

CDAD

May develop after withdrawn

87
Q

Aminoglycosides

A

Amikacin

Gentamicin

88
Q

BBW blood dyscrasias

A

Chloramphenicol

89
Q

Inhibitor of murein presursor synthesis

A

Fosfomycin

90
Q

BBW tendon rupture

91
Q

2nd gen ceph

92
Q

Metro side effects

A 
HA
GI
Metallic taste
Dark red brown urine
Neuropathy
93
Q

Piperacillin-tazobactam use

A

PEK (pseudomonas, enterobacter, klebsiella

94
Q

TMP/SMX use

A
  • UTIs
    MDR
    Pneumonia
95
Q

Bind 50S

A

Macrolides
Chloramphenicol
Clindamycin

96
Q

Vano side effects

A
  • ototoxic
  • nephrotoxic
  • red man syndrome
97
Q

5th gen ceph

A

Ceftaroline

98
Q

Tigecycline use

A

MRSA & VRE

99
Q

Linzeolid use

A

MDR
VRE
MRSA

100
Q

Avoided during pregnancy

A 
Aminoglycosides
Tetracycline
Sulfonamide
Trimethoprim
Fluoroquinolones
101
Q

Aztreonam resistance

A

Highly resistant to most B-lactamases

Except KPC

102
Q

BBW CDAD

A

Clindamycin

103
Q

What drug has transporter to cytosol?

A

Fosfomycin

104
Q

Ceftriaxone use

A

Meningitis

105
Q

Amoxicillin-clavulante use

A

Mixed infections
Nosocomial
URI

106
Q

Aminoglycosides MOA

A

Bactericidal
16S within 30S
Irreversible

Premature termination of protein synthesis

107
Q

Fidaxomicin MOA

A

RNA pol inhibitor

Bactericidal

108
Q

Cipro BBW

A

Tendon rupture

MG

109
Q

Clindamycin use

A

MRSA
Acne
Bacterial vaginosis

Pharmacology: Antibiotics (1 decks)

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