Antibiotics Flashcards
0
Q
How do B-lactamase inhibitors work
A
Bind irreversibly to B-lactamase (suicide inhibitors)
1
Q
Why penicillins have little dose related toxicity
A
Act on cell walls (humans do not have)
2
Q
Mechanisms of acquired penicillin resistance
A
Penicillin binding protein modification (low level - can be overcome with higher doses)
B-lactamases (high level - cannot be overcome)
Impermeability
4
Q
Examples of B-lactamase inhibitors
A
Clavulanate
Tazobactam
