Antibiotics

Question 1

Name 4 antibiotics that cover MRSA

Answer 1

Vancomycin
Linezolid
Daptomycin
Ceftaroline ( Vanc + ceftriaxone together)

Question 2

What broad spectrum antibiotics cover GRAM Positive, GRAM neg & Anaerobes

Answer 2

Pip - Tazo ( zosyn)
Carbapenems ( Ertapenem, meropenem, doripenem, imipenem

** Zosyn doesn’t cover ESBL well enough to be used in severe infections but probably works ok for UTI**

Question 3

Cephalosporins cover ______ & ______

Answer 3

Gram positive and gram negative

Good empiric ones for critical patients include : ceftriaxone, creepiness, ceftazidime

Question 4

Why shouldn’t we use linezolid for bloodstream infections

Answer 4

It is bacteriostatic ( but it can be used for VRE bacteremia)

Question 5

What two cephalosporins cover pseudomonas (gram negative aerobic)

Answer 5

Cefepime and ceftazidime

Question 6

What carbapanem does NOT COVER PSEUDOMONAS

Answer 6

Ertapenem

Question 7

For abdominal infections , what broad spectrum antibiotic single agents can be started

Answer 7

Zosyn 4.5 g q 6 h

Meropenem 1g IV q 8 h

Question 8

What regimens can be used to treat septic abortion ?

Answer 8

Zosyn 4.5 g q 8 h w/ or w/o Vancomycin

OR
Imipenem 500mg q 6 h

OR
Gentamicin 5 mg/kg IV day + Ampicillin 2g IV q4h + clinda 900mg IV q8H

OR

Gentamicin 5 mg/kg IV/day + Ampicillin 2g IV q4h + metronidazole 500 mg IV q8h

OR
Levofloxacin 500 mg IV/ day + metronidazole 500 mg IV q8H

Question 9

Gentamicin covers what bugs

Answer 9

Aerobic gram pos, some gram negs ( staph aureus and pseudomonas)

It is often added with a cephalosporin or penicillin to treat severe infections with E.coli, S. Aureus, Enterobacter, klebsiella, serratia, pseudomonas and other gram negatives