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naplex > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

What are some Atypical bacteria?

A

-Chlamydia
-Legionella
-Mycoplasma
-Mycobacterium

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2
Q

What are the stains for the different bacteria?

A

Gram + (dark purple) <–Think cell wall
Gram - (pink) <– Thin cell wall
Atypical (no stain) <–No cell wall

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3
Q

HNPEK meaning

A

H - H. influenzae
N - Neisseria sp.
P - Proteus mirabilis
E - E. coli
K - Klebsiella sp.

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4
Q

CAPES meaning

A

C - Citrobacter
A - Acinetobacter
P - Providencia & Pseudomonas
E - Enterobacter
S - Serratia

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5
Q

What is the meaning of VRE?

A

Vancomycin resistant enterococcus

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6
Q

What is the meaning of ESBL?

A

Extended-spectrum beta lactamases

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7
Q

What is the meaning of CRE?

A

Carbapenem resistant enterobacterales

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8
Q

Which antibiotic has a Boxed Warning for C. difficile?

A

Clindamycin

*Note that all antibiotics have the potential to cause c.diff. Clindamycin was the first to be associated with c.diff, hence the boxed warning.

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9
Q

What are the hydrophilic antibiotics?

A

1) Beta lactams
2) Aminoglycosides
3) Glycopeptides
4) Daptomycin
5) Polymyxins

*These are renally excreted!

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10
Q

What are the lipophilic antibiotics?

A

1) Quinolones
2) Macrolides
3) Rifampin
4) Linezolid
5) Tetracycline
6) Chloramphenicol

*These are hepatically cleared!
*These have excellent bioavailability, therefore their IV:PO is usually 1:1.

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11
Q

What are the concentration-dependent antibiotics?

A

1) Aminoglycosides
2) Quinolones
3) Daptomycin

*Goal is for high peak and low trough.
*We give large dose over a long interval

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12
Q

What are the time-dependent killing antibiotics?

A

1) Beta lactams (Penicillins, cephalosporins, carbapenems)

*Goal is to maintain drug level above MIC for most of the dosing interval
*We give a shorter dosing interval, continuous infusion.

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13
Q

MSSA Drugs

A

1) Penicillins
2) Cephalosporins

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14
Q

MRSA Drugs

A

1) Vancomycin
2) Linezolid
3) Daptomycin (not in pneumonia)
4) Ceftaroline
5) SMX/TMP
6) Doxycycline, Minocycline
7) Clindamycin

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15
Q

VRE Drugs

A

1) Penicillin G
2) Ampicillin
3) Linezolid
4) Daptomycin
5) Cystitis Only: Nitrofurantoin, Fosfomycin, Doxycycline

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16
Q

Atypical Drugs

A

1) Azithromycin, Clarithromycin
2) Doxycycline, Minocycline
3) Quinolones

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17
Q

Pseudomonas aruginosa drugs

A

1) Piperacillin/Tazobactam
2) Cefepime
3) Ceftazidime
4) Ceftazidime/Avibactam
5) Ceftolozane/Tazobactam
6) Carbapenems (except Ertapenem)
7) Ciprofloxacin, Levofloxacin
8) Aztreonam
9) Tobramycin
10) Polymyxin B

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18
Q

ESBL Drugs

A

1) Carbapenems
2) Ceftazidime/Avibactam
3) Ceftolozane/tazobactam

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19
Q

CRE Drugs

A

1) Ceftazidime/Avibactam
2) Meropenem/Vaborbactam
3) Imipenem/Cilastatin/Relebactam

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19
Q

Anaerobe Drugs

A

1) Metronidazole
2) Beta-lactam/Beta-lactamase inhibitor
3) Carbapenems
4) Cefotetan, Cefoxitin

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20
Q

How do Beta Lactam antibiotics work?

A

They inhibit bacterial cell wall synthesis by binding to Penicillin Binding Proteins (PBP)

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21
Q

What are the beta lactam antibiotics?

A

1) Penicillins
2) Cephalosporins
3) Carbapenems
4) Aztreonam

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22
Q

What are the Penicillin antibiotics?

A

1) Penicillin G, Penicillin VK
2) Amoxicillin, Ampicillin
3) Nafcillin, Oxacillin, Dicloxacillin (Anti-staph)
4) Amox/clauv, Amp/Sulbactam
5) Pip/Tazo

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23
Q

Penicillin G & VK coverage

A

Gram Positives (Strep, not Staph)

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24
Q

Amoxicillin and Ampicillin coverage

A

Gram Positives (Strep, not Staph) + Gram Negatives (HNPEK)

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25
Q

Amox/Clav and Amp/Sulbactam coverage

A

Gram Positive + Gram Negative (HNPEK) + MSSA + B. fragilis

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26
Q

Pip/Tazo coverage

A

Gram Positive + Gram Negative (HNPEK) + MSSA + B. fragilis + CAPES + Pseudomonas

*This is the only penicillin that is active against Pseudomonas.

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27
Q

Nafcillin, Dicloxacillin and Oxacillin

A

MSSA and Streptococci

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28
Q

What DONT Penicillins cover?

A

1) NO Atypicals
2) NO MRSA

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29
Q

Penicillins with their formulation

A

Penicillin VK: PO
Penicillin G: IV and IM
Amoxicillin: PO
Ampicillin: IV
Amox/Clav: PO
Amp/Sul: IV
Pip/Tazo: IV
Dicloxacillin: PO
Nafcillin and Oxacillin: IV

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30
Q

When NOT to choose a penicillin/cephalosporin/carbapenem for a patient?

A

1) Beta-lactam allergy
2) Risk of seizure

*All Penicillins, Carbapenems and Cephalosporins increase the risk of seizures if accumulation occurs.

*If a patient presents with a penicillin allergy, there is a risk of cross reactivity if given a cephalosporin or carbapenem…so avoid this!

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31
Q

First generation Cephalosporins & coverage

A

-Cefazolin (IV)
-Cephalexin (PO)

Covers Staph, Strep, PEK, mouth anaerobes

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32
Q

Second generation Cephalosporins & coverage

A

-Cefuroxime (IV/IM/PO)
-Cefotetan (IV/IM)
-Cefoxitin (IV/IM)

These have the same coverage as the first generation (strep, staph, PEK, mouth anaerobes) but added Gram negative (HNPEK) activity.

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33
Q

Third generation Cephalosporins & coverage

A

-Cefdinir (PO)
-Ceftriaxone (IV)
-Ceftazidime (IV) <– Pseudomonas coverage

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34
Q

Fourth generation Cephalosporins & coverage

A

-Cefepime

*Broad Spectrum: Gram +, HNPEK, CAPES, Pseudomonas

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35
Q

Fifth generation Cephalosporins & coverage

A

-Ceftaroline <–MRSA coverage

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36
Q

What does the cephalosporins NOT cover?

A

1) NO Enterococcus
2) NO Atypicals

37
Q

What are our main oral cephalosporins?

A

1) Cephalexin
2) Cefuroxime
3) Cefdinir

38
Q

What are the Carbapenem antibiotics?

A

1) Meropenem
2) Ertapenem
3) Doripenem
4) Imipenem/Cilastatin

*All IV

39
Q

When are Carbapenems preferred?

A

-They are the drug of choice for ESBL-producing organisms
-Pseudomonas (except ertapenem)
-Polymicrobial infections (Diabetic foot infections)
-Empiric therapy when resistant organisms are suspected

40
Q

What does Carbapenems NOT cover?

A

1) Atypicals
2) VRE
3) MRSA
4) C. diff

Ertapenem does not cover PEA (Pseudomonas, Enterococcus, Acinetobacter)

41
Q

What is the coverage of Aztreonam?

A

Gram negative organisms:
-Pseudomonas
-CAPES

*This can be used in patients with beta-lactam/penicillin allergy

42
Q

Which Beta-Lactam covers pseudomonas?

A

1) Ceftazidime, Ceftazidime/Avibactam
2) Aztreonam
3) Ceftolozane/Tazobactam
4) Cefepime
5) All Carbapenems except Ertapenem

43
Q

Which Beta-Lactam covers enterococcus?

A

1) Penicillin
2) Amoxicillin, Amoxicillin/Clav
3) Ampicillin/Sulbactam
4) Pip/Tazo
5) All Carbapenems except Ertapenem

44
Q

How do Aminoglycosides work?

A

They bind to the ribosome, which interferes with bacterial protein synthesis and results in a defective bacterial cell membrane.

45
Q

Coverage of Aminoglycosides

A

-Gram negatives (including Pseudomonas)
-Synergy with beta-lactams for gram positives (Staph & Enterococci)

46
Q

Dosing for Aminoglycosides

A

1) Traditional (1 - 2.5 mg/kg IV q8h)
Draw trough 30 min before 4th dose
Draw peak 30 mins after 4th dose infusion
Ideal Trough : <2

2) Extended Interval (4 - 7 mg/kg IV q24h)

47
Q

Toxicities of Aminoglycosides

A

1) Renal Damage
2) Ototoxicity (Ear)

*Avoid when taking with other Nephrotoxic drugs (AmpB, Cisplatin, Polymixins, Cyclosporine, Loop Diuretics, NSAIDs, Radiocontrast dye, Tacrolimus, Vancomycin)

48
Q

What are the Aminoglycoside drugs?

A

-Gentamicin
-Tobramycin
-Amikacin

49
Q

How do Quinolones work?

A

They inhibit bacterial DNA topoisomerase and DNA gyrase. This promotes breakage of double-stranded DNA.

50
Q

What are the Boxed Warnings for Quinolones?

A

1) Tendon rupture (usually Achilles)
2) Peripheral Neuropathy
3) CNS effects (seizures)

*Use last-line

51
Q

What are the main Quinolone drugs?

A

1- Ciprofloxacin
2- Levofloxacin
3- Moxifloxacin
4- Delafloxacin

52
Q

Notes about Quinolones

A

-They interact with cations (antacids)
- They can cause QT prolongation and cause psych disturbances

53
Q

Coverage of Quinolones

A

Broad-Spectrum:
-Gram + & -
-Atypicals

Levo and Moxi are considered Respiratory Quinolones, since they are active against Strep pneumoniae.

Cipro and Levo have enhanced activity against pseudomonas, UTI, traveler’s diarrhea.

Moxi have anaerobic activity, and can be used alone for polymicrobial infections. It is the only quinolone that cannot be used for a UTI.

Delafloxacin has MRSA coverage

54
Q

How do Macrolides work?

A

They bind to the 50s ribosomal subunit, resulting in the inhibition of the RNA-dependent protein synthesis.

55
Q

Coverage of Macrolides

A

-Atypicals
-Respiratory infections (H. influenzae, S. pneumoniae)

56
Q

What are the Macrolide drugs?

A

-Azithromycin
-Clarithromycin
-Erythromycin

57
Q

Macrolide Drug interactions?

A

Erythromycin and Clarithromycin are CYP3A4 inhibitors, and are contraindicated with simvastatin and lovastatin.

They cause QT prolongation

58
Q

How do Tetracyclines work?

A

They inhibit bacterial cell wall synthesis by reversibly binding to the 30s ribosomal subunit.

59
Q

What are the Tetracycline drugs?

A

1) Tetracycline
2) Doxycycline
3) Minocycline

60
Q

What is the coverage of Tetracyclines?

A

-Gram Positive (Staph, Strep, MRSA)
-Gram Negative (Respiratory flora: Haemophilus, Moraxella)
-Atypicals
-VRE (Vanco Resistant Enterococcus)

61
Q

Notes about Tetracyclines

A

-Avoid use in children < 8 years, breastfeeding and pregnancy
-Photosensitivity
-Interacts with divalent cations (Antacids)
-Minocycline: causes DILE (Drug induced lupus erythematosus)

62
Q

How do Sulfonamides (Sulfamethoxazole) work?

A

Sulfamethoxazole inhibits dihydrofolic acid formation, which interferes with bacterial folic acid synthesis.

Trimethoprim inhibits the folic acid pathway.

63
Q

Notes about Bactrim (Sulfamethoxazole/Trimethoprim)

A

1) Dose is based on Trimethoprim
2) NO breastfeeding, pregnancy,
3) Sulfa Allergy
4) Photosensitivity
5) SJS
6) Do not use if patient has G6PD deficient

64
Q

Common uses of Bactrim

A

-Uncomplicated UTI
-MRSA
-Pneumocystis pneumonia

65
Q

What is the ratio of Sulfamethoxazole to Trimethoprim?

A

5:1 SMX/TMP

66
Q

Coverage of Bactrim

A

-Staph (MRSA)
-Gram negative

NO Coverage for pseudomonas, enterococci, atypicals or anaerobes

67
Q

What antibiotics are primarily used for Gram Positive infections?

A

1) Vancomycin
2) Lipoglycopeptides
3) Daptomycin
4) Linezolid

68
Q

Coverage of Vancomycin

A

-MRSA
-Streptococci
-Enterococci
-C- difficile (Oral only)

69
Q

Dosing of Vancomycin

A

15-20 mg/kg q8-12h (TBW)

If CrCl 20-49: q24h
-Red Man Syndrome with rapid infusion.

-This is a nephrotoxic drug! Monitor CrCl.
-Avoid other nephrotoxic and ototoxic drugs (furosemide, aminoglycosides, cisplatin).

70
Q

What are the Lipoglycopeptide drugs?

A

“vancin”

-Telavancin
-Oritavancin
-Dalbavancin

*They have similar coverage as Vancomycin (they are structurally similar)

71
Q

How do Lipoglycopeptides work?

A

They inhibit bacterial cell wall synthesis by blocking polymerization and cross-linking of peptidoglycan, and changing cell wall permeability.

72
Q

How does Daptomycin work?

A

This inhibits intracellular replication processes including protein synthesis and causes cell death.

73
Q

Daptomycin coverage

A

MRSA + VRE

*No activity against Gram Negative organisms and pneumonia bugs.

74
Q

Warning of Daptomycin

A

-Rhabdomyolysis
-Myopathy

75
Q

What are the Oxazolidinone drugs?

A

-Linezolid
-Tedizolid

76
Q

How do Linezolid work?

A

They bind to the 50s subunit of the bacterial ribosome, inhibiting translation and protein synthesis.

77
Q

Coverage of Linezolid

A

-MRSA
-VRE

78
Q

Safety of Linezolid

A

These have Serotonergic properties.

-Do not use within 14 days of an MAO inhibitor. (Contraindicated)

Side Effects: Serotonin syndrome, myelosuppression, optic neuropathy

79
Q

How does Clindamycin work?

A

This reversibly bind to the 50s subunit, inhibiting protein synthesis.

80
Q

Coverage of Clindamycin

A

-Strep & Staph
-MRSA
-Anaerobes

81
Q

How dose metronidazole work?

A

This cause a loss of helical DNA structure and strand breakage resulting in inhibition of protein synthesis.

82
Q

How does Fidaxomicin work?

A

This inhibits RNA polymerase, resulting in inhibition of protein synthesis and cell death.

First line for c. diff infections.

83
Q

How does Rifaximin work?

A

These inhibits bacterial RNA synthesis by binding to bacterial DNA-dependent RNA polymerase.

Used for Travelers diarrhea, prevention of hepatic encephalopathy.

84
Q

What are our Urinary Agents?

A

1) Nitrofurantoin
2) Fosfomycin
3) Bactrim

85
Q

How does Fosfomycin work?

A

Inhibits bacterial cell wall synthesis by inactivating the enzyme pyruval tansferase.

86
Q

Coverage of Fosfomycin

A

-E. coli (including ESBL)
-E. faecalis (including VRE)

87
Q

Coverage of Nitrofurantoin

A

-E. coli
-Klebsiella
-Enterobacter
-Staph aureus
-VRE

This is the drug of choice for Uncomplicated UTI.

Dosing: 100 mg BID x 5 days

88
Q

C. difficile drugs for treatment

A

1) Metronidazole
2) Vancomycin
3) Fidaxomicin

89
Q

Which drugs do NOT require Renal Adjustments?

A

1) Anti-staph Penicillins
2) Ceftriaxone
3) Clindamycin
4) Doxycycline
5) Azithromycin, Erythromycin
6) Metronidazole
7) Moxifloxacin
8) Linezolid

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