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Phase 1 Drugs > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

What is the MoA of penicillins? Are they bacteriocidal or -static? Concentration or time dependent?

A

Inhibit cell wall synthesis by binding penicillin binding proteins. Cidal. Time-dependent

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2
Q

What is the MoA of cephalosporins? Are they bacteriocidal or -static? Concentration or time dependent?

A

Inhibit cell wall synthesis. Cidal. Time-dependent

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3
Q

What is the MoA of carbapenems? Are they bacteriocidal or -static? Concentration or time dependent?

A

Inhibit cell wall synthesis. Cidal. Time-dependent.

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4
Q

What is the MoA of fluoroquinolones? Are they bacteriocidal or -static? Concentration or time dependent?

A

Nucleic acid/DNA synthesis inhibitor - inhibit topoisomerase II and IV. Cidal. Concentration-dependent.

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5
Q

What is the MoA of glycopeptides? Are they bacteriocidal or -static? Concentration or time dependent?

A

Inhibit cell wall synthesis. Cidal. Time-dependant.

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6
Q

What is the MoA of lincosamides? Are they bacteriocidal or -static? Concentration or time dependent?

A

Inhibit protein synthesis (50S ribosome). Static. Time-dependent.

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7
Q

What is the MoA of chloramphenicol?

A

Inhibits protein synthesis (50s ribosome). Static. Time-dependent.

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8
Q

What is the MoA of macrolides?

A

Inhibit protein synthesis (50s ribosome). Static. Time-dependent.

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9
Q

What is the MoA of metronidazole?

A

Inhibits nucleic acid/DNA synthesis - causes strand breaks and inhibits DNAase1. Cidal. Concentration-dependent.

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10
Q

What is the MoA of tetracyclines?

A

Inhibit protein synthesis (30s ribosome). Static. Time-dependent.

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11
Q

What is the MoA of polymixins?

A

Targets cell-membrane function by disturbing phospholipids. Cidal. Time-dependent

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12
Q

What is the MoA of aminoglycosides?

A

Inhibit protein synthesis (30s ribosome). Cidal. Concentration-dependent.

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13
Q

What is the MoA of sulfa drugs?

A

Inhibit folic acid synthesis for nucleic acid synthesis. Static (TMS is cidal). Time dependent.

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14
Q

What is the MoA of rifamycin?

A

Inhibits B subunits of DNA-dependent RNA polymerase, suppresses RNA synthesis. Static. Concentration-dependent for mycobacterium. Unknown for other tissues?

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15
Q

Which Abx concentrate in bile?

A

Clindamycin, erythromycin, doxycycline, rifampin

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16
Q

Which Abx cross the BBB?

A

Chloramphenicol, sulfonamides/trimethoprim, fluoroquinolones, metronidazole, 3rd generation cephalosporins

17
Q

What Abx cross the BBB with meningitis?

A

Penicillins, doxycycline/minocycline, rifampin, erythromycin

18
Q

Which Abx do NOT enter CSF?

A

Aminoglycosides, clindamycin, 1st and 2nd generation cephalosporins, vancomycin

19
Q

Which Abx penetrate the prostate?

A

Fluoroquinolones, clindamycin, chloramphenicol, TMS, doxycycline, erythromycin

20
Q

Which Abx are concentration dependent?

A

Fluoroquinolones, aminoglycosides, azithromycin, metronidazole

Phase 1 Drugs (4 decks)

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