Antibiotics

Question 1

Penicillins side effects

Answer 1

Hypersensitivity and skin reactions

Question 2

Flucloxacillin & co-amoxiclav

Answer 2

Cholestatic jaundice

Question 3

Clindamycin, cephalosporins & quinolones

Answer 3

C. difficile colitis

Question 4

Macrolides

Answer 4

GI disturbances, hepatitis, Q-T interval

Question 5

Quinolones

Answer 5

Q-T interval, convulsions, tendonitis

Question 6

Aminoglycosides/glycopeptides

Answer 6

Nephrotoxicity/ototoxicity

Question 7

Vancomycin

Answer 7

Vancomycin flushing syndrome (red person syndrome)

Question 8

Tetracyclines

Answer 8

Hepatotoxicity, staining teeth, photosensitivity, dysphagia

Question 9

Nitrofurantoin

Answer 9

Peripheral neuropathy, pulmonary fibrosis

Question 10

Sulphonamides (co-trimoxazole)

Answer 10

Stevens-Johnson syndrome, blood dyscrasias

Question 11

Trimethoprim

Answer 11

Blood dyscrasias

Question 12

Chloramphenicol

Answer 12

Aplastic anaemia, grey baby

Question 13

Linezolid

Answer 13

Blood dyscrasias, MAOI, optic neuropathy

Question 14

Sodium fusidate

Answer 14

Hepatotoxicity

Question 15

Absorption of tetracyclines & quinolones reduced by ___________ ?

Answer 15

Antacids/calcium

Question 16

Broad-spectrum antimicrobials and oral contraceptives

Answer 16

Entero-hepatic cycling can lead to contraceptive failure

Question 17

Broad spectrum antimicrobials and warfarin

Answer 17

Increased INR

Question 18

Metronidazole

Answer 18

Disulfiram-like interaction with alcohol

Question 19

Aminoglycosides/ glycopeptides/ colistin with loop diuretics or ciclosporin or tacrolimus

Answer 19

Nephrotoxicity

Question 20

Quinolones and steroids

Answer 20

Tendonitis

Question 21

Quinolones and NSAIDs

Answer 21

Convulsions

Question 22

Macrolides/ quinolones and Q-T prolonging drugs

Answer 22

**common

metabolised by P450 enzymes