Antibiotics Flashcards

1
Q

MOA of vancomycin?

A

Cell wall inhibitor
Inhibits Peptidoglycan synthesis

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2
Q

MOA of fosfomycin ?

A

Cell wall synthesis inhibitor
Inhibits peptidoglycan synthesis

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3
Q

Which class of ABs inhibit the cell wall synthesis? (5)

A

1) peptidoglycan inhibitors (vancomycin - fosfomycin)
2) penicillins ( end in -cillin)
3) cephalosporins
4)carbapenems
5)monobactams

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4
Q

Which ABs inhibit the cross linking of the peptidoglycans ?

A

Beta lactams

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5
Q

What are the 4 groups of beta lactams ?

A

1) monobactam
2) cephalosporins
3) cephamycin
4) carbapenem

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6
Q

What are the natural penicillins ? (2)

A

1)penG (IV - IM)
2)penV (PO)

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7
Q

What are the anti staphylococcal penicillins ? (3)

A

1) oxacillin
2) naphicillin
3) dicloxacillin

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8
Q

How many generations to cephalosporins have?

A

5

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9
Q

What are the first generation cephalosporins ? (2)

A

1) Cefazoline
2) cefalexin

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10
Q

What are the second generation cephalosporins ? (3)

A

1) cefaclor
2) cefaxitin
3) cefotitin

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11
Q

What are the third generation cephalosporins? (3)

A

1) ceftriaxone
2) cefotaxime
3) ceftazedime

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12
Q

what are the fourth generation cephalosporins? (1)

A

Cefepime

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13
Q

What are the 5th generation cephalosporins?

A

Cefteroline

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14
Q

Carbapenem coverage ?

A

Broad spectrum

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15
Q

What are the 4 carbapenem drugs ? (DIME)

A

Doripenem
Imipenem
Meropenem
Ertrapenem

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16
Q

Name a monobactam antibiotic ?

17
Q

What are the 4 beta lactamase inhibitors ?

A

Clavulanate
Sulbactam
Tazobactam
Avibactam

18
Q

What penicillin is mixed with clavulanate ?

A

Amoxicillin

19
Q

What antibiotic is mixed with avibactam ?

A

Ceftazidime

20
Q

What antibiotic is mixed with sulbactam ?

A

Ampicillin

21
Q

What antibiotic is mixed with tazobactam?

A

Pepracillin

22
Q

What are the antibiotics that destroy cell membrane integrity?

A

Daptomycin
Polymyxine

23
Q

What are the antibiotics that destroy cell membrane integrity?

A

Daptomycin
Polymyxine

24
Q

What are the antibiotics that destroy cell membrane integrity?

A

Daptomycin
Polymyxine

25
What are the antibiotics that inhibit the folic acid pathway?
Sulfamethoxazole (sulfunamides) Trimetoprime
26
What are the antibiotics that destroy DNA integrity?
Metronidazole Nitropharantoin
27
What antibiotic stops MRNA synthesis?
Rifampin
28
What is the MOA of rifampin ?
Inhibits MRNA synthesis
29
fluoroquinolone MOA ?
Inhibits DNA gyrase function
30
What is the first generation fluoroquinolone ?
Cipeofloxacin
31
What are the second generation fluoroquinolones ?
Levofloxacin Gemifloxacin Moxifloxacin
32
What are the protein inhibitor antibiotics ?
1) Macrolides (azithro-erythro-clorithro) 2) Clindamycin 3) Chloramphenicol 4) Lynezolid 5) Aminoglycosides ( gentamicin- Amikacin- tobramicin) 6) tetracyclines ( doxycycline- tetracycline)