Antibiotics

Question 1

Classification of antibiotics

Answer 1

1- cell wall synthesis inhibitors

1- beat lactam ( penicillin, cephalosporins, carbapenem and monobactam)
2- glycoproteins like vancomycin
3- not classified like batricin

Cell membran distributors like daptomycin and Polymyxin B

2- protein synthesis inhibitors
30 s units ( aminoglycosides , tigecycline and tetracycline)
50s units. ( clindamycin , linzolide , chloramphenicol, macrolides and streptogramines )

3- Nucleic acid synthesis inhibitors
Direct act on DNA ( quinolone)
Inhibit float like bactrim
Creat free radicals like Nitrofurantion and metronidazole

Question 2

Antibiotics cause Psudomembranous colitis?

Answer 2

Clindamycin , carbapenem, Ampicillin and Aztreonam

Question 3

What are the bugs not covered by carbapenem?

Answer 3

MRSA , Enterococcus facium, stenotrophomonas maltophila and Burkholdecia cepacia

Question 4

Common organisms with SCID / T cell defects

Answer 4

Intracellurar organisms ( listeria , salmonella, mycobacterium, ligonella , franshiella , Neisseria , brucellosis and Yersenia)
Virus ( EBV , CMV , paraflu)
Fungi/protozoa ( pcp and Candida)

Question 5

Common organisms with B-cell defect ?

Answer 5

Encapsulated organisms
Enteroviruses
Giardia and cryptosporidium

Question 6

Common organisms with phagocytic defect?

Answer 6

Staph , serratia and pseudomonas
Candida and aspergillosis

Question 7

Bacteria ferment lactose

Answer 7

E. coli , klebsiella, Enterobacter, citrobacter and serratia

Question 8

Rice water diarrhea

Answer 8

Vibrio cholera associated with undercooked raw shellfish

Question 9

Staph aureus viralunce factor

Answer 9

Protein A

Question 10

IgA protease virulence factor for which bacteria?

Answer 10

SHIN. Streptococcus pneumonia, H influenza type B and Neisseria

Question 11

Pigment-producing bacteria

Answer 11

Staphylococcus aureus—-yellow
Actinomyces isralli ——yellow sulfur granules
Serratia —-red
P.aeruginosa—-blue green

Question 12

Most common cause of invasive GAS infections

Answer 12

Varicella

Question 13

Indication to test for GAS

Answer 13

Fever , pain with swallowing, exudative pharyngitis and unilateral cervical lymph node enlargement and tenderness

Question 14

Different b/w post-streptococcal arthritis and ARF

Answer 14

Post-streptococcal not respond to NSAIDA

Question 15

Enterococcus resistance to ?

Answer 15

Cephalosporins except ( ceftaroline ), bactrim and clindamycin

Question 16

1,3 B glucan not present in 3 fungi

Answer 16

Cryptococcus, zygo and blastomyces