antibiotics

Question 1

penicillins MOA

Answer 1

cell wall synthesis inhibitors

Question 2

cephalosporins MOA

Answer 2

cell wall synthesis inhibitors

Question 3

polyene antifungals examples

Answer 3

amphotericin B

nystain

Question 4

echinocandins examples

Answer 4

micafungin
anidulafungin
caspofungin

Question 5

influenza A

Answer 5

all ages, all animals

causes moderate to severe illness

Question 6

influenza B

Answer 6

humans only, mainly children

causes milder epidemics

Question 7

influenza C

Answer 7

rare in humans

no epidemics

Question 8

polyenes AE

Answer 8

amphotericin B - nephrotoxicity

do not use in pregnancy

may need to premedicate w benadryl

electrolyte abnormalities

pulmonary toxicity

Question 9

flucytosine AE

Answer 9

neutropenia, thrombocytopenia

not used as monotherapy

Question 10

azoles AE

Answer 10

GI, HA, LFT elevation, hypoK, dyspnea, cough

drug interactions

flu/itra/vori - renal dosing

take w food

vori- vision changes

must give w inline filter

do not take w PPI

Question 11

influenza treatment & AEs

Answer 11

oseltamivir
zanamivir
peramivir

baloxavir

must be admin within 48 h of s/s!

AE - GI/LFTs, CNS, allergic, SJS/TEN, rash

Question 12

HSV treatment

Answer 12

for HSV-1 HSV-2, EBV, varicella

acyclovir
valacyclovir

shingrix vaccine
docosanol

Question 13

acyclovir/valacyclovir AEs

Answer 13

N/D, rash, HA

Question 14

chickenpox treatment

Answer 14

acyclovir IV for immunocompromised

varicella zoster IG

Question 15

CMV treatment

Answer 15

ganciclovir

valganciclovir

Question 16

ganciclovir/valganciclovir AE

Answer 16

myelosuppression, CNS, azotemia, rash

Question 17

hepatitis C treatment

Answer 17

NS3/4A protease inhibitors (-previr)
N4A complex inhibitors (-asvir)
NS5B polymerase inhibitors (-buvir)

Question 18

hep C treatment AEs

Answer 18

HA, fatigue, insomnia

Question 19

1st line treatment for hep C treatment naive patients

Answer 19

clecaprevir/pibrentasivir