Antibiotic Use in the ED Flashcards
Abx’s which Inhibit nucleic acid synthesis and how:
Sulphonamides – inhibits dihydropteroate synthetase (pre-DHFR step)
Trimethoprim – inhibits dihydrofolate reductase (DHFR)
Quinolones – inhibit DNA gyrase
Nitroimidazoles – Nucleic acid analogues
Abx’s which Inhibit cell wall synthesis:
Penicillins
Cephalosporins
Vancomycin
Abx’s which Inhibit protein synthesis
Aminoglycosides
Tetracyclines
Macrolides
Chloramphenicol
Every prescription needs…
Before prescribing, always assess for…
generic drug name, dose (including units), frequency, duration
medication allergies, warn about SE, and be aware of drug interactions
Abx’s used for Meningitis
Community acquired?
Brain abscess? ceftriaxone 2g IV q12h +/- metronidazole 500mg IV q12h
Community acquired: ceftriaxone, +/- vancomycin, +/- ampicillin
**Brain abscess: ** ceftriaxone, +/- metronidazole
Sinusitis
Abx for Acute?
Abx for Chronic?
Acute (<3 weeks): no ABX recommended
Chronic (>3 weeks): TMP-SMZ + amoxicillin/clavulanic acid, azithromycin, quinolone