Antibiotic coverage Flashcards
Natural PCN
G+ strep
G+ enterococcus
G + anaerobes
Aminopenicillin
G+ Strep
G+ enterococcus
G+ anaerobes
G- HNPEK
Aminopenicillin with BLi
G+ Strep G+ enterococcus G+ anaerobes G- HNPEK MSSA G- anaerobe
extended spectrum PCN
G+ Strep G+ enterococcus G+ anaerobes G- HNPEK MSSA G- anaerobe CAPES, pseudomonas
Antistaph PCN
MSSA
1st generation cephalosporin
G+ strep
G+ staph
G- PEK (not as great)
2nd generation cephalosporin
G+ strep
G+ staph
G- HNPEK
(2 drugs in this class cover G- anaerobe)
3rd generation cephalosporin
G+ strep
G+ staph
G+ anaerobe
G- HNPEK (including pseudomonas and MDR)
4th generation cephalosporin
G+ strep, staph, anaerobe
G- CAPES, HNPEK, pseudomonas
5th generation cephalosporin
G+ broad
G- HNPEK
MRSA
Carbapenems
G- including pseudomonas
G+
Anaerobes
All lack: MRSA, C.diff, VRE, Stenotrophomas
Ertapenem lacks: pseudomonas, enterococcus, and Acinetobacter
Monobactam
G- including pseudomonas and MDR GN
lacks G+ and anaerobe activity
aminoglycosides
G+ (streptomycin and gentamicin + BL or vanc)
G- including pseudomonas
streptomycin and amikacin 2nd line x mycobacterial infxns
FQ’s
G+ G- anaerobes Gem, Levo, Moxi--> Resp: S. pneumo, and atypicals Cipro and Levo--> G-; pseudomonas Moxi--> G+ and anaerobes, not x UTI Delaflox--> MRSA
Macrolides
Atypicals
[S. pneumo, Moraxella, Haemophilus, Neisseria]–> resistance growing towards these
STDs
Tetracyclines
Doxycycline (CAP, Ricketsia, Tick born (1st line), Spriochettes, CA-MRSA, VRE, STD
minocycline–> mainly x SSTI
Azithromycin DOC x
travelers diarrhea
Sulfonamides
G+: staph and strep (not as reliable)
G-: Haemophilus, Enterobacter, shigella, salmonella, stenotrophoma
opportunistic infxns: Toxoplasmosis, PCP, Nocardia
lacks: pseudomonas, enterococcus, atypicals and anaerobes
Vancomycin
MRSA (1st line)
Strep
Enterococcus
C. diff (PO Only)
Dalbavancin, telavancin, oritavancin
same as vanc without C. diff coverage
Daptomycin
similar to vanc but VRE (both)
Oxazolidinones
MRSA and VRE (both)
Synercid
MRSA and VRE (except E. faecalis)
Tygacil
G+ (MRSA and both VRE)
G: except 3 P’s: pseudomonas, proven, protesus
Atypicals
Anaerobes