Antibiotic coverage

Question 1

Natural PCN

Answer 1

G+ strep
G+ enterococcus
G + anaerobes

Question 2

Aminopenicillin

Answer 2

G+ Strep
G+ enterococcus
G+ anaerobes
G- HNPEK

Question 3

Aminopenicillin with BLi

Answer 3

G+ Strep 
G+ enterococcus 
G+ anaerobes 
G- HNPEK 
MSSA  
G- anaerobe

Question 4

extended spectrum PCN

Answer 4

G+ Strep 
G+ enterococcus 
G+ anaerobes 
G- HNPEK 
MSSA  
G- anaerobe 
CAPES, pseudomonas

Question 5

Antistaph PCN

Answer 5

MSSA

Question 6

1st generation cephalosporin

Answer 6

G+ strep
G+ staph
G- PEK (not as great)

Question 7

2nd generation cephalosporin

Answer 7

G+ strep
G+ staph
G- HNPEK
(2 drugs in this class cover G- anaerobe)

Question 8

3rd generation cephalosporin

Answer 8

G+ strep
G+ staph
G+ anaerobe
G- HNPEK (including pseudomonas and MDR)

Question 9

4th generation cephalosporin

Answer 9

G+ strep, staph, anaerobe

G- CAPES, HNPEK, pseudomonas

Question 10

5th generation cephalosporin

Answer 10

G+ broad
G- HNPEK
MRSA

Question 11

Carbapenems

Answer 11

G- including pseudomonas
G+
Anaerobes
All lack: MRSA, C.diff, VRE, Stenotrophomas
Ertapenem lacks: pseudomonas, enterococcus, and Acinetobacter

Question 12

Monobactam

Answer 12

G- including pseudomonas and MDR GN

lacks G+ and anaerobe activity

Question 13

aminoglycosides

Answer 13

G+ (streptomycin and gentamicin + BL or vanc)
G- including pseudomonas
streptomycin and amikacin 2nd line x mycobacterial infxns

Question 14

FQ’s

Answer 14

G+
G-
anaerobes 
Gem, Levo, Moxi--> Resp: S. pneumo, and atypicals
Cipro and Levo--> G-; pseudomonas 
Moxi--> G+ and anaerobes, not x UTI 
Delaflox--> MRSA

Question 15

Macrolides

Answer 15

Atypicals
[S. pneumo, Moraxella, Haemophilus, Neisseria]–> resistance growing towards these
STDs

Question 16

Tetracyclines

Answer 16

Doxycycline (CAP, Ricketsia, Tick born (1st line), Spriochettes, CA-MRSA, VRE, STD
minocycline–> mainly x SSTI

Question 17

Azithromycin DOC x

Answer 17

travelers diarrhea

Question 18

Sulfonamides

Answer 18

G+: staph and strep (not as reliable)
G-: Haemophilus, Enterobacter, shigella, salmonella, stenotrophoma
opportunistic infxns: Toxoplasmosis, PCP, Nocardia
lacks: pseudomonas, enterococcus, atypicals and anaerobes

Question 19

Vancomycin

Answer 19

MRSA (1st line)
Strep
Enterococcus
C. diff (PO Only)

Question 20

Dalbavancin, telavancin, oritavancin

Answer 20

same as vanc without C. diff coverage

Question 21

Daptomycin

Answer 21

similar to vanc but VRE (both)

Question 22

Oxazolidinones

Answer 22

MRSA and VRE (both)

Question 23

Synercid

Answer 23

MRSA and VRE (except E. faecalis)

Question 24

Tygacil

Answer 24

G+ (MRSA and both VRE)
G: except 3 P’s: pseudomonas, proven, protesus
Atypicals
Anaerobes

Question 25

Polymixin

Answer 25

Pseudomonas
Enterococcus 
E. coli 
Klebsiella 
(MDR GNR)

Question 26

Chloramphenicol

Answer 26

G+, G-, atypicals, anaerobes

Question 27

Clindamycin

Answer 27

G+ aerobes and anaerobes

Question 28

Metronidazole (only)

Answer 28

Anaerobes 
Protozoans (giardia and amebiasis) 
Bacterial vaginosis 
Trichomoniasis 
C. diff 
Intraabdominal infxn in combo with other abx

Question 29

Tinidazole

Answer 29

Protozoans (giardia and amebiasis)
Bacterial vaginosis
Trichomoniasis

Question 30

Secnidazole

Answer 30

Bacterial vaginosis

Question 31

Fosfomycin

Answer 31

E. coli and E. facaelis

Question 32

Fidoxamicin

Answer 32

C. diff

Question 33

Rifampin

Answer 33

E. coli

used x: travelers diarrhea, HE, IBS-D

Question 34

Nitrofurantoin

Answer 34

S. aureus 
E. coli 
Enterococcus (VRE)
Enterobacter 
Klebsiella

Question 35

Mupirocin Nasal ointment

Answer 35

MRSA nares