Antibioitcs Flashcards
what are the glycopeptides?
vancomycin and teicoplanin
what are the macrolides?
erythromycin, clindamycin, clarithromycin
what are the fluoroquinolones?
ciprofloxacin, norfloxacin, levofloxacin, moxifloxacin
what are the aminoglycosides?
gentamicin, streptomycin
what are the sulfonamides?
sulfamethoxazole, dapsone
what are the tetracyclins?
tetracycline, doxycycline, minocycline, tigecycline
what are the beta lactams?
penicillin, cephalosporin, carbapenems, monobactams
glycopeptide moa
glycopeptides very bulky, binds to d-ala dipeptide and blocks off transpeptidase
daptomycin moa
lipid tail inserted into membrane forming an ion conducting channel from which K+ ions can leak out.
this depolarises the membrane causing cell death
fosfomycin moa
binds to cysteine residue, inactivating bacterial cell wall enzyme Mur A which catalyses the first step of peptidoglycan synthesis
sulfa moa
sulfa similar to PABA, inhibit first step of folate pathway
trimethoprim moa
inhibits dihydrofolicacid reductase, inhibitng the last step
tetracyclin moa
binds to 30s subunit prevents tRNA from binding to A site
aminoglycoside moa
binds to 30s subunit causing mismatching of mRNA and tRNA which creates junk proteins
chloramphenicol moa
binds to 50s subunit and prevents transpeptidation reaction
macrolides moa
binds to 50s subunit and interferes with peptide chain synthesis
fluoroquinolone moa
inhibits topoisomerases involved in DNA supercoiling
rifampicin moa
RNA polymerase inhibitor
