Antibacterial agents

Question 1

Any compound natural, synthetic or semi synthetic that is clinically useful in the treatment of bacterial infection

Answer 1

Antibacterial

Question 2

Agents that inhibit bacterial growth

Answer 2

Bacteriostatic

Question 3

Agents that generally kill only growing organism

Answer 3

Bactericidal

Question 4

Preferrentially active against either Gram negative or Gram positive

Answer 4

Narrow spectrum

Question 5

Is active against both Gram negative and Gram positive

Answer 5

Broad spectrum

Question 6

Discovered by Alexander Fleming in 1920

Answer 6

Penicillin

Question 7

Antibiotic of choice for infections caused by methicillin staphylococci and penicillinase producing enterococci

Answer 7

Vancomycin

Question 8

Similar to dihydrofollic acid is bound by dihydrofolate reductase

Answer 8

Trimetropin

Question 9

Classification of antibacterial agents

Answer 9

1. inhibit cell wall
2. inhibit nucleotide synthesis
3. inhibit nucleic acid synthesis
4. inhbits protein synthesis

Question 10

Mechanism of drug resistance(strategy)

Answer 10

1. pathogen prevents entry of the drug
2. Presence of membrane translocases that pumps drug out of the cell.
   “efflux pumps”
3. Drug inactivation through chemical modification
   ex. Hydrolysis

Question 11

Substance produced by microorganisms that in minute quantities is able to inhibit other microorganisms

Answer 11

Antibiotics