antiarrythmics Flashcards
What are the drugs of class Ia?
quinidine, procainamide, disopyramide
what do the drugs of class Ia do?
blocks inward potassium at normal concentration
blocks fast Na at high concentration
depress phase 0 and increase AP duration
what are the drugs of class ib?
Lidocaine and Mexiletine
What do the drugs of class Ib do?
blocks Na+ in inactive state
What are the drugs of class Ic?
Flecainide, propafenone, moricizine
What do the drugs of class Ic do?
blocks sodium channels, depresses phase 0
What are the drugs of class II?
beta blockers
propanolol, metoprolol, carvedilol, esmolol
What is do the drugs of class II do?
decrease SA and AV node activity and phase 4 depolarization
What are the drugs of class III?
sotalol, ibutilide, dofetilibide, amiodarone, dronedarone
What do the drugs of class III do?
K+ blockade, prolong repolarization
What are the drugs of class IV?
verapamil and dilitiazam
What do the drugs of class IV do?
block L type calcium channels, slow AVN and SAN
What does adenosine do?
dec cAMP, inc IKach
what does digoxin do?
blocks na/k pumps, slows AVN, positive inotropic
What is the treatment for acute afib/flutter?
digoxin, beta blockers, class IV
What is the treatment for chronic afib/flutter?
digoxin, beta blockers, class IV
control sinus rhythm: class III
What is the treatment for acute SVTs?
IV adenosine, class IV
What is the treatment for chronic SVTs?
beta blockers, digoxin , class Ic, class III, Class IV
What is the treatment for nonsustained VT?
asymptomatic - no treatment
symptomatic - beta blockers
what is the treatment for sustained VT/VFIB?
amiodarone and ICD
What is the treatment for glycoside induced VT?
digoxin FAB fragments
What is the treatment for drug induced Tdp?
discontinue offending drug, magnesium sulfate
What is the treatment for WPW?
amiodarone and procainamide
Which arrythmias require cardioconversion?
Vflutter, v fib
What else besides antiarrythmics would you give some with afib?
anticoagulants
What arrythmias can vagal stimulation treat?
paroxysmal SVT and AVN reentry