antiarrythmics Flashcards
What are the drugs of class Ia?
quinidine, procainamide, disopyramide
what do the drugs of class Ia do?
blocks inward potassium at normal concentration
blocks fast Na at high concentration
depress phase 0 and increase AP duration
what are the drugs of class ib?
Lidocaine and Mexiletine
What do the drugs of class Ib do?
blocks Na+ in inactive state
What are the drugs of class Ic?
Flecainide, propafenone, moricizine
What do the drugs of class Ic do?
blocks sodium channels, depresses phase 0
What are the drugs of class II?
beta blockers
propanolol, metoprolol, carvedilol, esmolol
What is do the drugs of class II do?
decrease SA and AV node activity and phase 4 depolarization
What are the drugs of class III?
sotalol, ibutilide, dofetilibide, amiodarone, dronedarone
What do the drugs of class III do?
K+ blockade, prolong repolarization
What are the drugs of class IV?
verapamil and dilitiazam
What do the drugs of class IV do?
block L type calcium channels, slow AVN and SAN
What does adenosine do?
dec cAMP, inc IKach
what does digoxin do?
blocks na/k pumps, slows AVN, positive inotropic
What is the treatment for acute afib/flutter?
digoxin, beta blockers, class IV