Antiarrythmics Flashcards by Vishnu Patel | Brainscape

Q

Class 1A antiarrythmics

A

Na+ channel blockers

Decrease slope of phase 0 (medium)

Increase action potential duration

Disopyramide, Quinidine, Procainamide

Atrial and Ventricular arrthymias

Toxicity: Prolonged QT (Torsades de pointes)

Procainamide: SLE-like symptoms

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Q

Quinidine

A

Class IA Na+ channel blockers

Decrease slope of phase 0 (medium)

Increase action potential duration

Atrial and Ventricular arrthymias

Toxicity: Prolonged QT (Torsades de pointes)

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Q

Disopyramide

A

Class IA Na+ channel blockers

Decrease slope of phase 0 (medium)

Increase action potential duration

Atrial and Ventricular arrthymias

Toxicity: Prolonged QT (Torsades de pointes)

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Q

Procainamide

A

Class IA Na+ channel blockers

Decrease slope of phase 0 (medium)

Increase action potential duration

Atrial and Ventricular arrthymias

Toxicity: Prolonged QT (Torsades de pointes)

SLE-like symptoms

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Q

Class 1B antiarrythmics

A

Na+ channel blockers

Lidocaine, Tocainide, Mexiletine

Decrease slope of phase 0

Shortens action potential length

Acute ventricular arrythmias (post-MI)

and digitalis-induced arrythmias

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Q

Class 1 C antiarrythmics

A

Na+ channel blocker

Flecainide, propafenone

Decrease slope of phase 0

No change in action potential duration

Ventricular tachycardia that progress to VF

or intracible SVT

Contraindicated post-MI

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Q

Lidocaine

A

Class IB Na+ channel blockers

Decrease slope of phase 0

Shortens action potential length

Acute ventricular arrythmias (post-MI)

and digitalis-induced arrythmias

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Q

Tocainide

A

Class IB Na+ channel blockers

Decrease slope of phase 0

Shortens action potential length

Acute ventricular arrythmias (post-MI)

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Q

Mexiletine

A

Class IB Na+ channel blockers

Decrease slope of phase 0

Shortens action potential length

Acute ventricular arrythmias (post-MI)

and digitalis-induced arrythmias

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Q

Flecainide

A

Class IC Na+ channel blocker

Decrease slope of phase 0

No change in action potential duration

Ventricular tachycardia that progress to VF

or intracible SVT

Contraindicated post-MI

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Q

Propafenone

A

Na+ channel blocker

Decrease slope of phase 0

No change in action potential duration

Ventricular tachycardia that progress to VF

or intracible SVT

Contraindicated post-MI

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Q

Class II antiarrythmics

A

Beta-blockers

Decrease cAMP, decrease Ca++ currents

Decrease slope of phase 4 in pacemakers

Increase PR interval (slower AV node conduction)

Ventricular tach, SVT, atrial fibrillation and atrial flutter

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Q

Class III antiarrythmics

A

K+ channel blocker

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