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Pharm quiz 8 > Antiarrhythmics > Flashcards

Antiarrhythmics Flashcards

1
Q

Class 1A

A

Increase action potential duration

  • Quinidine
  • Procainamide
  • Disopyramide
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2
Q

Class 1B

A

Shorten duration of action potential and refractory period

  • Lidocaine
  • Mexiletine
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3
Q

Class 1C

A

Little or no effect on duration of action potential or refractory period

  • Flecainide
  • Propafenone
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4
Q

Class II

A

Beta Blockers

Propanolol
Metropolol
Timolol

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5
Q

Class III

A

K channel blockers

Sotalol - torsades / CHF
Ibutilide - torsades, Long Q-T
Dofetilide - Bradycardia, Hypokalemia
Amiodarone - CYP 3A4, CYP 450, adrs below

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6
Q

Class IV

A

Ca channel blockers

Supraventricular Arrhythmias
Verapamil
Diltiazem

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7
Q

Class I, general

A

Na channel blockers, local anesthetic action

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8
Q

Quinidine (Class 1A) ADRs

A

Atrail flutter / fibrillation
Ventricular Arrhythmias

Torsades
Syncope
Hypotension
GI

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9
Q

Procainamide (Class 1A) ADRs

A

Best for Ventricular Arrhythmias

Torsades
Syncope
Hypotension
GI

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10
Q

Disopyramide (Class 1A) ADRs

CYP450

A

Ventricular Arryhthmias

Torsades de Pointes
CHF symptoms
QT prolongation

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11
Q

Lidocaine (Class 1B)

A

** 1st line Ventricular Arrhythmias from MI **

Hypotension
Neuro: lightheadedness, tremor, hearing disturbances

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12
Q

Mexeletine (Class 1B) ADRs

A

Not used any more? Chronic Ventricular Arrhythmias?

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13
Q

Flecainide (Class 1C) ADRs

A

A Fib

May cause severe exacerbation of arrhythmias w pre existing ventricular tachy / previous MI

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14
Q

Propafenone (Class 1C) ADRs

A

Atrail Fib, Atrial Flutter

Beta Blocker Effect

Hypotension
Constipation
Metallic taste

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15
Q

Drug of choice for prompt conversion of paroxysmal supraventricular tachycardia to sinus rhythm

A

Adenosine

ADRs -
SOB
Hypotension
Headache
Nausea
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16
Q

Used in:
Digitalis induced arrhythmias
Torsade de pointes
Sinus tachycardia

A

Magnesium

17
Q

decreases conduction of electrical impulses through the AV node and increases vagal activity via its central action on the CNS

A

Digoxin

18
Q

Amiodarone ADRs

A 
Blue skin, 
bradycardia,
abnormal liver function tests
corneal opacity / blindness, 
pulm toxicity,

Pharm quiz 8 (2 decks)

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