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CV Pharmacology > Antiarrhythmics > Flashcards

Antiarrhythmics Flashcards

1
Q

What are the adverse effects of Procainamide?

A
  • hypotension
  • reversible SLE-like syndrome
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2
Q

What are the adverse effects of Quinidine?

A
  • cinchonism
  • diarrhea
  • thrombocytopenia
  • increase in digitalis toxicity
  • Torsades de pointes
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3
Q

What are the adverse effects of Disopyramide?

A
  • heart failure
  • antimuscarinic effect
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4
Q

What are the adverse effects of Lidocaine/Mexiletine?

A
  • local anesthesia
  • CNS depression/elevation
  • CV depression
  • allergies
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5
Q

What are the adverse effects of Flecainide/Propafenone?

A
  • arrhythmias, especially post-MI
  • CNS toxicity
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6
Q

What are the adverse effects of Dofetilide/Ibutilide?

A
  • Torsades de pointes
  • bradycardia
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7
Q

What are the adverse effects of Amiodarone?

A
  • pulmonary fibrosis
  • hepatotoxicity
  • hypo/hyperthyroidism
  • corneal deposits
  • blue-gray skin deposits
  • neurologic effects
  • constipation
  • CV depression
  • NO TORSADES
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8
Q

What are the adverse effects of Verapamil/Diltiazem?

A
  • constipation
  • flushing
  • dizziness
  • edema
  • SA & AV block
  • hypotension
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9
Q

What are the adverse effects of Adenosine?

A
  • flushing
  • hypotension
  • chest pain
  • transient asystole
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10
Q

What are the adverse effects of K+?

A
  • reentrant arrhythmias
  • fibrillation
  • cardiac arrest
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11
Q

What are the adverse effects of Magnesium?

A
  • muscle weakness in overdose
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12
Q

What are the adverse effects of Digoxin?

A
  • arrhythmias (atrial & ventricular premature contraction, paroxysmal atrial tachycardia w/block, ventricular tachycardia)
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13
Q

What classes are used to treat reentry ventricular tachycardia & fibrillation?

A
  • Class I (except Ic)
  • class III
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14
Q

What classes are used to treat ventricular tachycardia?

A
  • amiodarone
  • lidocaine
  • procaineamide
  • sotalol or flecainide if no MI or CHD
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15
Q

What classes are used to treat reentry atrial fibrillation and flutter?

A
  • rhythm control
    • class I and class III
  • rate control
    • CCBs, beta-blockers, warfarin
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16
Q

What classes are used to treat supraventricular tachycardias?

A
  • class IV, class II, digoxin
  • class III agents with sceondary characteristics: amiodarone, sotalol
17
Q

What classes are used to treat AV nodal reentry (paroxysmal supraventricular tachycardia)?

A

Adenosine

18
Q

Which drugs should not be used to treat arrhythmias in pts with strutural and ischemic heart disease?

A

Flecainide, Propafenone (class IC)

19
Q

Which drugs should not be used in pts with CHF?

A

Dronedarone, Amiodarone, Sotalol, Verapamil, Diltiazem, beta-blockers

20
Q

Which drug should not be used in pts with Wolff-Parkinson-White syndrome?

A

Digoxin - can cause ventricular fibrillation

21
Q

Amiodarone inhibits which CYP enzymes?

A
  • CYP2C9 - Wafarin
  • CYP2D6 - some beta-blockers
  • CYP3A4 - CCBs
22
Q

Which drugs are associated with Torsades de pointes?

A
  • Quinidine
  • Dofetilide, Ibutilide
  • Sotalol
23
Q

What drugs are used to treat Digitalis-induced arrhythmias?

A
  • Mg2+
  • K+
  • Lidocaine (IB)

CV Pharmacology (5 decks)

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