Antiarrhythmic Drugs

Question 1

Procainamide

Answer 1

Class IA antiarrhythmic

Uses: afib conducting down AVBT

Side effects: hypotension, agranulocytosis, drug-induced lupus

Question 2

Lidocaine

Answer 2

Class IB antiarrythmic

Uses: VF and VT

Side effects: GI and CNS

Question 3

Propafenone

Answer 3

Class IC antiarrhythmic

Uses: SVT, also has beta-blocker effect

Side effects: proarrhythmia

Other: hepatic & renal metabolism

Question 4

Sotalol

Answer 4

Class III antiarrhythmic

Uses: VT, SVT, beta-blocker effect

Side effects: QT prolongation/torsade de pointes

Other: renal metabolism

Question 5

Amiodarone

Answer 5

Class III antiarrhythmic

Uses: broad spectrum antiarrhythmic, heart failure

Side effects: high toxicity - thyroid, liver, lungs, eye, photosensitivity

Question 6

Ibutilide

Answer 6

Class III antiarrhythmic

Uses: afib, atrial flutter

Side effects: QT prolongation/torsade de pointes

Other: renal metabolism

Question 7

Adenosine

Answer 7

Increases outward K current in SA & AV nodes but not ventricles (decreases sinus rate and nodal conduction)

Question 8

Digoxin

Answer 8

Uses: slows AV node conduction, increases contractility