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Antiarrhythmic > Antiarrhythmic > Flashcards

Antiarrhythmic Flashcards

1
Q

1A

A

Prcainamide(cholinolytic)

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2
Q

1B

A

Lidocaine

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3
Q

1C

A

Ethacizine,propafenon,flecainidine

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4
Q

Ethacizine

A

Class4 property

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5
Q

Propafenon

A

Class2and4property

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6
Q

Flecainid

A

Class 3property

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7
Q

2nd class antiarrhythmic

A

BAB

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8
Q

3rd class antiarrhythmic

A

Amiodarone,sotalol,vernakalant

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9
Q

Amiodarone has

A

1a,2 and4 property

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10
Q

Sotalol(3) also has property of

A

Class 2

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11
Q

Vernakalant also has property to

A

1b

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12
Q

Class 4 antiarrhythmic

A

Verapamil and diltiazem

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13
Q

Non classified antiarrhythmic

A

Magnesium sulphate, Atropine,Digoxin, Epinephrine (MADE)

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14
Q

Phase 0 of SAN and AVN is provided by

A

Depolarisation -calcium flux

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15
Q

Phase 3 of SAN and AVN is provided by

A

Repolarization (K flux)

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16
Q

Phase 4 of SAN and AVN is provided by

A

Both calcium and Na flux(slow diastolic depolarization)

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17
Q

Phase 0 of contractile Myocardium and his- purkinje is provided by

A

Na flux

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18
Q

Phase 1 of contractile M is provided by

A

K flux

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19
Q

Phase 2of CM are provided by

A

Calcium flux

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20
Q

Phase 3 of CM and His- purkinje are provided by

A

K flux

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21
Q

Phase 4 is (CM)

A

Polarization or resting phase

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22
Q

Systole happens in

A

0 to 3 rd phase

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23
Q

Diastole happens in

A

Phase 4

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24
Q

Arrythmia are

A

Change in origin of rhythm, change in HR,change in regularity, disturbance in conduction of impulse

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25
Q

Hemodynamics

A

Rhythm and frequency

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26
Q

Class 2 and 4 acts on

A

Inhibits phase 0 and 4 of SA and AV phases

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27
Q

Class 1a inhibits phase

A

0 and 3 of CM

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28
Q

Class 1b and 1c inhibits

A

Phase 0 of CM

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29
Q

Class 3inhibits

A

Phase 3 of CM

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30
Q

Lidocaine only act against

A

Ventricular arrythmia

31
Q

Calcium channel blockers indication

A

Only for supraventricular arrythmia

32
Q

ECG of 1a class

A

QRS and QT prolongation

33
Q

For 1b ecg

A

QT become short

34
Q

1c ecg

A

QRS prolongation

35
Q

Dissociation kinetics 1a,b,c

A

Medium,fast,slow

36
Q

Drug affinity on na channel of 1a and c

A

Open is more than inactivated

37
Q

Na channels are inactivated during

A

Phase 1,2 and3

38
Q

Na channels are open in

39
Q

Prcainamide is

A

Na and K channel blocker

40
Q

Clinical use of prcainamide

A

Treatment of SVA and VA

41
Q

Side effects of prcainamide

A

Hypotension, lupus erythematous syndrome, proarryhthmic effect,Torsades de pointes(TdP)

42
Q

Because of fast dissociation kinetics of 1b

A

No change in QRS complex duration

43
Q

Clinical use of lidocaine

A

VA treatment

44
Q

Side effects of Lidocaine

A

CNS toxicity (seizures)

45
Q

Lidocaine has

A

First pass metabolism

46
Q

Class 1 c use

47
Q

Side effects of class 1c

A

Heart failure

48
Q

All class 3 ecg

A

Prolonged QT interwal

49
Q

Amiodarone is

A

Na channel blockers, potassium channel blockers,beta blockers and calcium channel blockers

50
Q

Amiodarone doe

A

1a,3,2,and4 class mechanism

51
Q

In 2 and 4 class mechanism

A

Negative chronotropy,dromotropy and inotropy happens

52
Q

Negative chronotropy

A

Increased RR interval

53
Q

Negative dromotropy

A

Increased PR interval

54
Q

Use of amiodarone

A

Both SVA and VA

55
Q

Side effects of amiodarone

A

Hypo or hyperthyroidism,pneumofibrosis, photo toxicity, hepatotoxicity,blue skin pigmentation (smurf skin),corneal deposition, rarely Tdp

56
Q

Amiodarone toxicity

A

Bradyarrythmia , ventricular arrythmia

57
Q

Amiodarone is structural similar to

58
Q

Major life threatening toxicity of amiodarone

A

Pulmonary toxicity

59
Q

Amiodarone toxicity treatment

A

QRS prolongation, bradyarrythmia and hypotension can be treated by sodium bicarbonate
Torsades de pointes with magnesium

60
Q

Vernakalant has

A

Class 3 and 1 b mechanism,so prolonged QT and QRS normal ,because of fastDK

61
Q

Vernakalant use

A

Acute Afib treatment

62
Q

Side effects of vernakalant

A

Hypotension and bradycardia

63
Q

Beta blockers and calcium channel blockers

A

Negative chronotropy dromotropy and inotropy

64
Q

Use of BAB

A

Frequency control of SVA and VA treatment

65
Q

Clinical use of Calcium channel blockers

A

Frequency control of SVA

66
Q

Magnesium sulphate

A

Reduces calcium flow in ventricular cardiomyocyte-Tdap treatment

67
Q

Atropine has

A

Positive chrono and dromotropy

68
Q

Atropine use

A

Sinus bradycardia and AV block

69
Q

Epinephrine has

A

Positive chrono,dromotropy and inotropy effect

70
Q

Epinephrine is used in

71
Q

Digoxin has

A

Positive inotropic effect,but negative dromotropy and chronotropy,so use to treat SVA

72
Q

Treatment of Digoxin toxicity

A

Potassium, magnesium aspartate,phenytoin against ventricular tachycardia and Digoxin immune Fab antibodies

73
Q

Class 1 a and 3 can cause

A

Prolonged QT interwal syndrome

74
Q

Prolonged QT interwal syndrome can be congenital or aquired

A

Medication affecting hERG (K channel for repolarization)

Antiarrhythmic (1 decks)

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