Antiarrhythmia Drugs

Question 1

Normal Rhythm: Generation of impulse is _____ bpm and is Initiated by __ node

Answer 1

60-100 bpm

SA node

Question 2

Conduction of impulse is Through normal pathways and Through pathways at normal velocities, if it deviated from this it produces ______.

Answer 2

If it deviates from this it is arrhythmia

Question 3

Ion channel function can be disturbed by:

6 things

Answer 3

1. Inherited mutation/polymorphism
2. Acute ischemia
3. Sympathetic stimulation
4. Myocardial scarring
5. Inflammation
6. Drugs

Question 4

examples of drugs that can disturb ion channel function

Answer 4

Beta blockers, calcium channel blockers, macrolides, etc

Question 5

how does Myocardial scarring affect ion channel function?

Answer 5

Conduction doesn’t go through scarred tissue as well, can cause arrhythmia