Antianemic drugs Flashcards
1
Q
Where is iron best absorbed?
A
- Duodenum and proximal jejunum
2
Q
How should iron be taken?
A
- Not with food, phosphates, tannates and phytate in food bind iron and prevent its absorption.
- 2 hrs before or 4 hrs after antacids
- Iron salt best absorbed in mildly acidic form, 250 mg Vit C or half glass of orange juice.
3
Q
What is iron dextran used for?
A
- Parenteral, IV or IM
- Must test with small amount for allergies
- Blood loss, IBS, kidney, cancer, heart disease
4
Q
What is ferric gluconate complex used for?
A
- IV infusion lower incidence of allergy
5
Q
When is iron sucrose used?
A
- IV only
- Limited to 300mg every 2-3 weeks
- Combined with EPO to prevent anemia in dialysis patients
6
Q
What is ferumoxytal and its use?
A
- Supermagnetic rion naoparticle
- Rapid IV for kidney disease
7
Q
What is ferric carboxymaltose?
A
- Stable complex for 15 min IV of 1000mg pre week
- Up to 1500 mg
8
Q
What are the side effects of iron IV?
A
- Fever, arthralgia, myalgia, constipation, diarrhea, thick green stool
- Self limiting
- Corticosteroids given theraputically
- Inflammation in arthritis patients
- 1-2g fatal in children
- Desferoximine for OD
9
Q
What are the erythrocyte factors?
A
- Iron
- B 12
- EPO
10
Q
What are the granulocyte factors?
A
- Filgrastim (G-CSF)
- Sargramostim (GM-CSF)
11
Q
What are the platelet factors?
A
- Oprelvekin (IL-11)
- Romiplostim
- Eltrombopag
12
Q
What are the two forms of cyanocobalamin in the body and their function?
A
- Methylcobalamin- HCN–> methionine
- Adenosylcobalamin- Methylmalonyl-Co–> succinyl-Co
13
Q
What are the 3 EPO therapies and there use?
A
- Erythropoietin
- Darbepoietin
- Methoxy poly ethyl glycol poietin
- Anemias, marrow suppressive therapies, to decrease need for transfusions.
14
Q
What is the primary function of filgrastim?
A
- Increases neutrophil production and activity
15
Q
What is the primary function of sargramostim?
A
- More general granulocyte stimulator
