Anti-Viral

Question 1

osteltamivir (PO)

Answer 1

MOA: INH of release of virus from infected cell
AE: in flu pts: fatal neuropsychiatric
Organisms: influenza A and B

Question 2

zanamivir (inhalation)

Answer 2

MOA: INH of release of virus from infected cell
AE: DO NOT USE w/ pulm dx = fatal bronchospasm
Organisms: influenza A and B

Question 3

amantadine (PO)

Answer 3

MOA: INH of viral entry or uncoating
AE: neurologic, nausea, orthostatic hypoTN
- contraindicated w/ glaucoma and breastfeeding
Organisms: influenza A

Question 4

rimantadine (PO)

Answer 4

MOA: INH of viral entry or uncoating
AE: minimal
Organisms: influenza A

Question 5

ribavirin (inhalation, IV)

Answer 5

MOA: INH of viral nucleic acid synthesis
AE: flu-like symtoms, BBW: hemolytic anemia & teratogenicity
Organisms: RSV, human metapneumovirus, hantavirus

Question 6

cidofovir (IV)

Answer 6

MOA: DNA polymerase INH
AE: neurologic, hemtaologic, tubular damage, BBW: renal impairment
Organisms: adenovirus

Question 7

acyclovir (IV)

Answer 7

MOA: DNA polymerase INH
AE: HA, nausea, hepatotoxicity, nasopharyngitis, neutropenia, reno-toxic
Organisms: varicella-zoster virus

Question 8

valacyclovir (PO)

Answer 8

• prodrug for acyclovir
  MOA: DNA polymerase INH
  AE: HA, nausea, hepatotoxicity, nasopharyngitis, neutropenia, reno-toxic
  Organisms: varicella-zoster virus