Anti-VEGF Flashcards
1
Q
What are the anti-VEGFs?
A
- Bevacizumab
- Sunitinib
2
Q
What is the mechanism of action of bevacizumab?
A
Prevents VEGF binding to receptors
3
Q
What is the half life of bevacizumab?
A
20 days
4
Q
What are the indications for bevacizumab?
A
- CRC
- NSCLC
- Ovarian
- Glioblastoma
5
Q
What are the adverse effects associated with bevacizumab?
A
- VTE
- HTN
- Proteinuria
6
Q
What are the drug-drug interactions of bevacizumab?
A
- Anthracyclines
- Thoracic RT
- Irinotecan
7
Q
What is the mechanism of action of Sunitinib?
A
Multi-targeted TKI
- VEGF
- KIT
- PDGF
- RET
8
Q
What is the PPB for sunitinib?
A
95%
No BBB
9
Q
How is Sunitinib metabolised?
A
CYP3A4
10
Q
How is sunitinib eliminated?
A
Faeces
11
Q
What is the half life of sunitinib?
A
48 hours
12
Q
What are the indications for sunitinib?
A
- GIST
- enal cell
- pancreatic NET
13
Q
What are the adverse effects associated with sunitinib?
A
- HTN
- VTE
- LV dysfucntion
- hair and skin depigmentation
- rash
- diarrhoea
