Anti TB Drugs

Question 1

Name the first-line Anti-TB drugs

Answer 1

1) Rifamycins
2) Pyrazinamide
3) Isoniazid
4) Ethambutol

Question 2

What are the second-line Anti-TB drugs

Answer 2

1) Para-aminosalicylic acid (PAS)
2) Ethionamide
3) Capreomycin

Question 3

Which two Anti-TB drugs are pro-drugs?

Answer 3

Isoniazid and pyrazinamide

Question 4

Which enzyme converts isoniazid into its active form?

Answer 4

KatG

Question 5

Which enzyme converts pyrazinamide into its active form?

Answer 5

Pyrazinioc acid

Question 6

Which Anti-TB drugs are bactericidal?

Answer 6

Both of the prodrugs and bedaquiline

Question 7

Which drug is a structural analog of PABA and inhibits folic acid synthesis?

Answer 7

PAS

Question 8

Which drug inhibits ATP production by blocking the proton pump in ATP synthase?

Answer 8

Bedaquiline

Question 9

Which drug interacts with NAD and NADP to produce adducts that inhibit DHFR and synthesis of mycolic acid?

Answer 9

Isoniazid

Question 10

Which drug inhibits mycobacterial synthesis and doesn’t have any other clear mechanism of action?

Answer 10

Capreomycin

Question 11

Which drug inhibits arabinosyl transferases?

Answer 11

Ethambutol

Question 12

Which drug inhibits enoyl-ACP reductase and leads to cell wall synthesis impairment?

Answer 12

Ethionamide

Question 13

Which drug binds to and inhibits RpsA and inhibits four different things inside the cell?

Answer 13

Pyrazinamide