Anti-TB Flashcards
Briefly summarise the course of TB treatment
6 months
2 months intensive phase: daily Rifampicin, Isoniazid, Pyrazinamide, Ethambutol (RIPE)
4 months continuation phase: daily or 3x/week rifampicin and isoniazid (RI)
What are the first line Anti-TB drugs?
Remember RIPE + Streptomycin
R: Rifampicin
I: Isoniazid
P: Pyrazinamide
E: Ethambutol
Common adverse effects and DDI of Rifampicin
- Hepatotoxicity
- Orange discolouration of bodily fluids
- DDI with CYP450 enzyme inhibitor
Can Rifampicin be used during pregnancy?
Yes
As a precaution, mothers and neonates born to mothers who have been under treatment with Rifampicin should be given vitamin K to avoid postpartum haemorrhage.
Is dose adjustment for Rifampicin needed for patients with renal impariment?
No.
What supplement should be given to pregnant mothers taking Isoniazid?
Pyridoxine (Vitamin B6)
Why is pyridoxine given to patient at risk of peripheral neuropathy?
To prevent B6 deficiency
Isoniazid is best taken ____
on an empty stomach
How long should antacid be separated from Isoniazid
2 hours
Common adverse effects of Isoniazide
- Hepatotoxicity
- Peripheral Neuropathy
Can pyrazinamide be used in patient with kidney failure?
Yes, but requires dose reduction
Common adverse effects of pyrazinamide
- Hepatotoxicity
- Photosensitivity
- Hyperuricemia
Adverse effects of Ethambutol
- Visual toxicity
- Hyperuricemia
Can ethambutol be used for patients with liver impairment
Yes
Can ethambutol be used for patients with renal impairment
Yes. Dose reduction required
