Anti-psychotics Flashcards
high potency typical
block D2 rec
advantages- not sedating, injectable, depot, inexpensive
disadvantages- EPS
low potency typical
block D2 rec
advantages- highly sedating, inheritable, inexpensive
disadvantages- highly sedating, QT prolong, EPS risk, anti-HAM
antiH1: sedation, weight gain
anti a1- orthostatic hypotension, cardiac abnl
anti-m- dry mouth, blurry vision, constipation, urinary retain, glaucoma
atypical
block D2 and 5HT2A rec
less EPS/prolactin release
haloperidol (haldol)
high potency typical
depot form
fluphenazine (prolixin)
high pot typical
depot form
chlorpromazine (thorazine)
low pot typical
also used to tx hiccups
antiHAM
thioridazine (mellaril)
low pot typical
anti HAM
clozapine (clozaril)
atypical
most efficacious (tx refractory pts, substance abuse, persistent positive symptoms, suicidal/violent) but most dangerous
most metab syndrome/weight gain
antiHAM- seizures, agranulocytosis (weekly blood draw for first 6 months)
decrease risk of suicide (like Li)
least risk for EPS (tx Tardive dyskinesia)
risperidone (risperdal)
atypical
depot form, sublingal disintegrating form most potent
more effective for short term tx than halloo
prolactinemia/EPS in doses >6mg/day (most similar to typical, moderate weight gain risk)
quetiapine (seroquel)
atyprical
antiHAM
orthostatic hypotension, sedation, longer dose titration (9 days to max dose?)
lowest risk of EPS/TD
olanzapine (zyprexa)
atypical
depot form, sublingual disintegrating form
available- fast
highest risk metal syndrome, weight gain, sedation
ziprasidone (geodon)
atypical
lowest risk metal syndrome/weight gain
QT prolong, best when given with food
aripiprazole (abilify)
atypical
partial agonist- longest slim half life
depot form
low risk of metab syndrome/weight gain, or sedation
more activating (akathisia) at higher doses
paliperidone (invega)
atypical (expensive)
depot form
does not require hepatic metabolism (active metabolite)
asenapine (saphris)
atypical (expesnive)
must be taken sublingually
risk of EPS