Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psych Pharm > Anti-Psychotics > Flashcards

Anti-Psychotics Flashcards

You may prefer our related Brainscape-certified flashcards:
Psychology 101 flashcards GRE® Psychology flashcards
1
Q

Chlorpromazine [Thorazine]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: juandice, skin rxn, impair glucose tolerance, anti-diuretic, OrthoHypo, CVD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Fluphenazine [Modecate]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Haloperidol [Haldol]

A

Typical 1st Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: IV/IM admin, erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Clozapine [Clozaril]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome
Dose Limit: blood dyscrasis (agranulocytosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Risperidone [Risperdal]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP at low dose, inc at high dose
DOC in child/teen
PK: active metabolite Paliperadone, depot available
erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Olanzapine [Zyprexa]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome (highest)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Quetiapine [Seroquel]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome (intermediate)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Ziprasidone [Geodon]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a/1a/2c Antagonist -> Inh negative symptoms, limited ESP
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome (intermediate/low)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Aripiprazole [Abilify]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> red full agonist and min positive symptoms
5HT-2a Antagonist/5HT-1a partial agonist -> Inh negative symptoms, reduce ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: minimal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lurasidone [Latuda]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist/5HT-1a partial agonist -> Inh negative symptoms
Still risk of ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Perphenazine [Trilafon]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Partial Agonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Trifluoperazine [Stelazine]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Partial Agonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Psych Pharm (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions