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Psych Pharm > Anti-Psychotics > Flashcards

Anti-Psychotics Flashcards

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1
Q

Chlorpromazine [Thorazine]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: juandice, skin rxn, impair glucose tolerance, anti-diuretic, OrthoHypo, CVD

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2
Q

Fluphenazine [Modecate]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

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3
Q

Haloperidol [Haldol]

A

Typical 1st Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: IV/IM admin, erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

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4
Q

Clozapine [Clozaril]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome
Dose Limit: blood dyscrasis (agranulocytosis)

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5
Q

Risperidone [Risperdal]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP at low dose, inc at high dose
DOC in child/teen
PK: active metabolite Paliperadone, depot available
erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA

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6
Q

Olanzapine [Zyprexa]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome (highest)

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7
Q

Quetiapine [Seroquel]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist -> Inh negative symptoms, reduce ESP
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome (intermediate)

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8
Q

Ziprasidone [Geodon]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a/1a/2c Antagonist -> Inh negative symptoms, limited ESP
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: Inc risk DMII, weight gain, metabolic syndrome (intermediate/low)

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9
Q

Aripiprazole [Abilify]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> red full agonist and min positive symptoms
5HT-2a Antagonist/5HT-1a partial agonist -> Inh negative symptoms, reduce ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: minimal

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10
Q

Lurasidone [Latuda]

A

Atypical 2nd Gen Anti-Psychotic
MoA: D2 Antagonist -> Inh positive symptoms
5HT-2a Antagonist/5HT-1a partial agonist -> Inh negative symptoms
Still risk of ESP
Low Potency -> Inc Anti-Cholinergic (min ESP)
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA

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11
Q

Perphenazine [Trilafon]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Partial Agonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

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12
Q

Trifluoperazine [Stelazine]

A

Phenothiazene, Typical 1st Gen Anti-Psychotic
MoA: D2 Partial Agonist -> Inh positive symptoms, Inc prolactin
Anti-Cholinergic -> minimize ESP
High Potency -> Inc ESP, less anti-cholingeric
PK: erratic absorp, high Vd (lipid high ProBind), cross placenta/milk, 2D6/3A4 meta (not ind)
DDI: Inh 2D6 -> Inc SSRI/TCA
ADE: acute dystonia, akathesia, parkinsonian, neuroleptic malignant syndrome, perioral tremor, tardive dyskinesia

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Psych Pharm (8 decks)

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