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Pharm > Anti-Neoplastics > Flashcards

Anti-Neoplastics Flashcards

1
Q

Alkylating Agents

-Whole cycle

A 
Bischlorethamines
   Mechlorethamine
   Cyclophosphamide
Nitrosureas
Procarbazine
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2
Q

Procarbazine SE

A

Leukemogenic

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3
Q

Platinum Complexes

-Whole Cycle

A

Cisplatin

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4
Q

Platinum SE

A

Oto/nephrotoxic

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5
Q

Anti-Tumor Antimetabolites

-S phase

A

Methotrexate-DHFR
Leucovorin rescue
Pyrimidine antag-
Cytarabine-deoxycytidine kinase (act.)
Capecitabine-thymidine phosphorylase (act.)
5-FU-blocks thymidylate synthetase
SE: diarhea and BM
Purine antag-XO breaks down, allopurinol sens.
6-MP: requires HGPRT
6-TG
Cow’s milk has XO

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6
Q

Anti-biotics

A

Bleomycin-No BM supp, whole cycle
SE: pulm fibrosis and anaphylaxis
Daunorubicin-cardiac toxic - S
Doxorubicin-cardiac toxic - S

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7
Q

DNA intercalation subsets

A

Alklyating agents
Platinum
Antitumor antimetabolites
Antibiotics

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8
Q

Intracellular Protein Interaction subsets

A

Mitotic spindle poisons-M phase

Topoisomerase inhibitors-S phase

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9
Q

Topoisomerase inhibitors

A 
Topo 1
   Camptothecans: 
      Irinotecan-diarrhea
      Topotecan
Topo 2
   Etoposide
   Dauno/Doxorubicin
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10
Q

Mitotic Spindle Poisons

A

Vinca Alkyloids-block MT polymerization
Vinblastine - blast BM
Vicristine-neuropathy
Paclitaxel-neuropathy-block MT disassembly

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11
Q

Hormones

A

Prednisone
Breast Cancer
SERM:
Tamoxifen: incr risk of clots/uterine CA
Raloxifene: decr risk of clots/uterine CA
Aromatase inhib: use in Post-meno women
Anastrozole
Letrozole
Exemestane
Prostate CA:
Leuprolide-continuous vs. pulsatile rel-GnRH analog
Flutamide-androgen R antagonist

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12
Q

Targeted Agents: EGFR

A

CEL
Cetuximab
Erlotinib
Lapatinib (HER2 also)

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13
Q

Targeted Agents: HER2

A

Lapatinib

Trastuzimab

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14
Q

Targeted Agents: bcr/abl kinase inhibitor

A

Imatinib-CML

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15
Q

Targeted Agents: anti-CD30

A

Bretuximab vedotin

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16
Q

Oncogene activation: arrest at _____

A

G1/S

17
Q

TS inactivation overrides arrest at _____

A

G2/M

18
Q

Mechanisms of Methotrexate resistance

A

DHFR gene amplification
DHFR gene mutation
Decreased methotrexate uptake
Increased drug efflux

19
Q

Types of Chemo

A

Induction: 1st line treatment
Neoadjuvant: pre-surgery
Adjuvant: post surgery
Salvage: 2nd/3rd line treatment

20
Q

Liver Metabolism/Kidney Clearance drugs

A 
Liver Metabolism
    Anthracyclines
    Vincristine
Kidney Clearance
    Cisplatin

Pharm (4 decks)

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