Anti- Malarials Flashcards
Classification of Drugs, Pathophysiology and potential ways to suppress them
Three potential ways to control malaria
Vector control
Drug therapy
Vaccination
(4) other names of Malaria
Intermittent fever
The fever
Marsh fever
Ague
Break bone fever
DENGUE
Classification of Anti- Malarial Drugs
Cinchona Alkaloids 4- Aminoquinolines 8- Aminoquinolines Polycyclic anti malarial drugs Fixed combination
Clinical manifestations of Malaria
fever, chills, and flu-like illness.
Quinine Sulfate indications
- Nocturnal leg cramps
2. Chloroquine resistant P. falciparum strain
Quinine Sulfate side effect
Abortifacient
Lethal for all Plasmodium schizonts and gametocytes from P. vivax and P. malariae
Quinine Sulfate
Potent antimalarial but is primary indicated for cardiac arrythmias
Quinidine
Chloroquine (Aralen)
Prophylaxis and treatment of malaria
DOC for erthyrocytic stage of falciparum malaria
Amiodarone (Cardorone)
Prophylaxis for malaria
Mefloquine (Ariam)
Schizonticide (newest member)
DOC for malarial suppression
Narrowest spectrum of activity
Primaquine
Most effective against malarial parasite in the liver but not effective within erythrocytes
Primaquine
Primaquine
DOC acute attack of Plasmodium
Cinchonism manifestations
tinnitus, headache, nausea, disturbed vision
Doxycycline
Prophylaxis for malaria
Halfantrine
Can arrest tissue conduction in cardiac muscles
Schizonticide
Lumefantrine MOA
Inhibition of B- hematinin
Most toxic antimalarial drug
Quinacrine
Causes the yellow color on the skin
Acridine dye
Quinacrine
Tx. for malarial and a SCLEROSING AGENT
Semi- synthetic antimalarial agent
Artemissinin
CINCHONA ALKALOIDS
Quinine Sulfate
Quinidine