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PHARMACOLOGY > Anti- Malarials > Flashcards

Anti- Malarials Flashcards

Classification of Drugs, Pathophysiology and potential ways to suppress them

1
Q

Three potential ways to control malaria

A

Vector control
Drug therapy
Vaccination

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2
Q

(4) other names of Malaria

A

Intermittent fever
The fever
Marsh fever
Ague

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3
Q

Break bone fever

A

DENGUE

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4
Q

Classification of Anti- Malarial Drugs

A 
Cinchona Alkaloids
4- Aminoquinolines
8- Aminoquinolines
Polycyclic anti malarial drugs
Fixed combination
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5
Q

Clinical manifestations of Malaria

A

fever, chills, and flu-like illness.

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6
Q

Quinine Sulfate indications

A
  1. Nocturnal leg cramps

2. Chloroquine resistant P. falciparum strain

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7
Q

Quinine Sulfate side effect

A

Abortifacient

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8
Q

Lethal for all Plasmodium schizonts and gametocytes from P. vivax and P. malariae

A

Quinine Sulfate

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9
Q

Potent antimalarial but is primary indicated for cardiac arrythmias

A

Quinidine

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10
Q

Chloroquine (Aralen)

A

Prophylaxis and treatment of malaria

DOC for erthyrocytic stage of falciparum malaria

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11
Q

Amiodarone (Cardorone)

A

Prophylaxis for malaria

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12
Q

Mefloquine (Ariam)

A

Schizonticide (newest member)

DOC for malarial suppression

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13
Q

Narrowest spectrum of activity

A

Primaquine

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14
Q

Most effective against malarial parasite in the liver but not effective within erythrocytes

A

Primaquine

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15
Q

Primaquine

A

DOC acute attack of Plasmodium

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16
Q

Cinchonism manifestations

A

tinnitus, headache, nausea, disturbed vision

17
Q

Doxycycline

A

Prophylaxis for malaria

18
Q

Halfantrine

A

Can arrest tissue conduction in cardiac muscles

Schizonticide

19
Q

Lumefantrine MOA

A

Inhibition of B- hematinin

20
Q

Most toxic antimalarial drug

A

Quinacrine

21
Q

Causes the yellow color on the skin

A

Acridine dye

22
Q

Quinacrine

A

Tx. for malarial and a SCLEROSING AGENT

23
Q

Semi- synthetic antimalarial agent

A

Artemissinin

24
Q

CINCHONA ALKALOIDS

A

Quinine Sulfate

Quinidine

25
Q

4- Aminoquinolines

A

Mefloquine
Amodiaquine
Chloroquine

26
Q

8-Aminoquinolines

A

Primaquine

27
Q

Polycyclic Anti-Malarial Drugs

A 
Doxycycline
Halfantrine
Lumefantrine
Quinacrine
Artemisinin

PHARMACOLOGY (2 decks)

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