Anti-Inflammatory Drug Targets

Question 1

What are the Cromolyns- Antiinflammatory drugs?

Answer 1

Sodium cromolyn

Question 2

What is the mechanism of the Cromolyns?

Answer 2

act on the chloride channels of mast cells to prevent them from being hyperresponsive

Question 3

Waht are the inhaled corticosterodis-antiinflammatory drugs?

Answer 3

Beclomethasone
Budesonide
Triamicinolone

Question 4

What are the oral corticosteroids-antiinflammatory drugs?

Answer 4

Prednisone, prednisolone

Question 5

What are the Leukotriene Receptro Blockers-Antiinflammatory drugs>

Answer 5

Montelukast,

Zafirlukast

Question 6

What are the IgE-antibody-antiinflammatory drugs?

Answer 6

Omalizumab

Question 7

What are the PDE4 Inhibitor drugs?

Answer 7

Roflumilast

Question 8

What do corticosteroids block?

Answer 8

the AA pathway prior to AA formation

Question 9

WHat to NSAIDS block?

Answer 9

The cox palthway and so get more asthma attackes when taking asprin

Question 10

What the are leukotriene blocker and inhibitors’ actions?

Answer 10

inhibiton of sysnthesis
block down stream mediators
interupt the recrutment of various inflammator mediator
-recptor traget, and syntheseis

Question 11

What two drugs act on Mast cells?

Answer 11

Sodium cromolyn
Omlizumab
stop mast cell from relesing histamine

Question 12

sodium cromylin use?

Answer 12

Proflalatic, or allergen

Question 13

anti-IgE use?

Answer 13

soaks up the extra IgE so that you cant produce a response - so not having a response from an allergen etc

Question 14

What are the antihistamines groups?

Answer 14

1st generation and 2nd generation
1 fundenmetal break up – have the ability to pass across BBB -1st generation
2nd generation can not cross BBB

Question 15

What are the mechanisms of antihistamines?

Answer 15

H1 receptors- throguhout the body, enphasisi in the lungs etc
inverse agoinits– binds to the receptor shifts to a balance into an inactive conformation – interup signalling
broncho contrscition, and loss of blood to periphery, and wheal and flare response
H2- receptors in the stomach

Question 16

What is phsophdiesterase?

Answer 16

enzyme responsivble for the break down of cAMP to inactive form

Question 17

How do phosphodiesterage inhibitors work?

Answer 17

inhibit the breakdown of cAMP, which is a direct inhibitor of the immune response – relaxation of airway smooth muscle, suppression of inflammatory cell function, inhibitiorn of air way smooth muscle proliferation

Question 18

What is the mechanism of TNF-alpha ?

Answer 18

does lots of stuff!!! beneficial and non beneficial!!!– ^some type of malignacy
Bind to TI or TII receptors- which dictates what type of response is needed– while bound can also act as a receptor, because things can bind to them and elicit an effect

Question 19

What is the mechanism of TNF-alpha inhibitors?

Answer 19

drugs taht neutralize soluble TNF-alpha, Binds transmembrane TNF-alpha, Inhibits transmembran cytokine cleavage
-many are antibody drugs, (CDC/ADCC)

Question 20

What results from TNF-alpha inhibitors?

Answer 20

CDC/ADCC; apoptosis, and PMN death

Question 21

What is a very adverse effect of TNF-alpha inhibitors?

Answer 21

lineing up of TNF-alpha causing a superagonist

Question 22

What are the TNF-alpha drugs

Answer 22

Etranercept
Inflixiimab
Adalimumab
Certolizumab pegol