Anti-Inflammatory Drug Targets Flashcards
What are the Cromolyns- Antiinflammatory drugs?
Sodium cromolyn
What is the mechanism of the Cromolyns?
act on the chloride channels of mast cells to prevent them from being hyperresponsive
Waht are the inhaled corticosterodis-antiinflammatory drugs?
Beclomethasone
Budesonide
Triamicinolone
What are the oral corticosteroids-antiinflammatory drugs?
Prednisone, prednisolone
What are the Leukotriene Receptro Blockers-Antiinflammatory drugs>
Montelukast,
Zafirlukast
What are the IgE-antibody-antiinflammatory drugs?
Omalizumab
What are the PDE4 Inhibitor drugs?
Roflumilast
What do corticosteroids block?
the AA pathway prior to AA formation
WHat to NSAIDS block?
The cox palthway and so get more asthma attackes when taking asprin
What the are leukotriene blocker and inhibitors’ actions?
inhibiton of sysnthesis
block down stream mediators
interupt the recrutment of various inflammator mediator
-recptor traget, and syntheseis
What two drugs act on Mast cells?
Sodium cromolyn
Omlizumab
stop mast cell from relesing histamine
sodium cromylin use?
Proflalatic, or allergen
anti-IgE use?
soaks up the extra IgE so that you cant produce a response - so not having a response from an allergen etc
What are the antihistamines groups?
1st generation and 2nd generation
1 fundenmetal break up – have the ability to pass across BBB -1st generation
2nd generation can not cross BBB
What are the mechanisms of antihistamines?
H1 receptors- throguhout the body, enphasisi in the lungs etc
inverse agoinits– binds to the receptor shifts to a balance into an inactive conformation – interup signalling
broncho contrscition, and loss of blood to periphery, and wheal and flare response
H2- receptors in the stomach
What is phsophdiesterase?
enzyme responsivble for the break down of cAMP to inactive form
How do phosphodiesterage inhibitors work?
inhibit the breakdown of cAMP, which is a direct inhibitor of the immune response – relaxation of airway smooth muscle, suppression of inflammatory cell function, inhibitiorn of air way smooth muscle proliferation
What is the mechanism of TNF-alpha ?
does lots of stuff!!! beneficial and non beneficial!!!– ^some type of malignacy
Bind to TI or TII receptors- which dictates what type of response is needed– while bound can also act as a receptor, because things can bind to them and elicit an effect
What is the mechanism of TNF-alpha inhibitors?
drugs taht neutralize soluble TNF-alpha, Binds transmembrane TNF-alpha, Inhibits transmembran cytokine cleavage
-many are antibody drugs, (CDC/ADCC)
What results from TNF-alpha inhibitors?
CDC/ADCC; apoptosis, and PMN death
What is a very adverse effect of TNF-alpha inhibitors?
lineing up of TNF-alpha causing a superagonist
What are the TNF-alpha drugs
Etranercept
Inflixiimab
Adalimumab
Certolizumab pegol
