Anti-inflammatory

Question 0

4 glucocorticoids

Answer 0

Flunisolide
Fluticasone
Budesonide
Prednisone

Added to treat RA before DMARDS kick in

Question 1

4 treatments for RA

Answer 1

Acetaminophen
NSAIDS
Glucocorticoids
DMARDS

Question 2

5 NSAIDS

Answer 2

Aspirin
Ibuprofen
Naproxen
Diclofenac
Indomethacin

Question 3

3 anti-TNFs

Answer 3

Adalimumab
Infliximab
Etanercept

Question 4

5 DMARDS

Answer 4

Abatacept
Azathioprine
MMF
Cyclophosphamide
(Anti-TNFs)

Question 5

Selective COX 2 inhibitor

Answer 5

Celecoxib

Question 6

COX 3 inhibitor

Answer 6

Acetaminophen

Question 7

2 Calcineurin inhibitors

Answer 7

Cyclosporine-NFAT
Tacromilus- NFAT
(Sarcolimus -mTOR inhibition)

Question 8

Cyclosporine

Answer 8

MAO: calcineurin inhibitor
Indications: organ transplant, autoimmune disease, GVHD
Toxicity: renal dysfunction, hypertension, diabetes

Question 9

Tacromilus

Answer 9

MAO: calcineurin inhibitor
Indications: organ transplant, autoimmune disease, GVHD
Toxicity: renal dysfunction, hypertension, diabetes

Question 10

Transplantation drugs

Answer 10

Azathioprine
Cyclosporine
Tacromilus

Question 11

6 Anti-Gout

Answer 11

NSAID
Glucocorticoids
Colchicine
Allopurinol
Fubexostat
Probenecid

Question 12

Colchicine

Answer 12

MAO: cytoskeletal inhibitor, blocks microtubule polymerization which blocks the migration and degranulation of neutrophils, and interferes with inflammasome formation to prevent release of IL-1B and thus inflammation
Indications: gout
Toxicity: none

Question 13

Probenecid

Answer 13

MAO: inhibits uric acid reabsorption in kidneys to increase excretion by blocking URAT 1 transporter
Indications: gout
Toxicity: none

Question 14

Allopurinol

Answer 14

MAO: blocks xanthine oxidase and thus production of uric acid
Indications: gout
Toxicity: cannot take with Aza because xanthine oxidase metabolizes it

Question 15

Febuxostat

Answer 15

MAO: xanthine oxidase inhibitor
Indications: gout
Toxicity: cannot take with Aza because xanthine oxidase metabolizes it

Question 16

Infliximab

Answer 16

MAO: anti-TNF biologic, neutralizes TNF and reduces inflammation
Indications: RA, crohn’s disease, psorasis, ankylosing spondylitis
Toxicity: infections, hep B, TB, sepsis, heart failure, liver failure

Often combined with methotrexate

Question 17

Adalimumab

Answer 17

MAO: anti-TNF biologic, neutralizes TNF and reduces inflammation
Indications: RA, crohn’s disease, psorasis, ankylosing spondylitis
Toxicity: infections, hep B, TB, sepsis, heart failure, liver failure

Often combined with methotrexate

Question 18

Etanercept

Answer 18

MAO: anti-TNF biologic, neutralizes TNF and reduces inflammation
Indications: RA, crohn’s disease, psorasis, ankylosing spondylitis
Toxicity: infections, hep B, TB, sepsis, heart failure, liver failure

Often combined with methotrexate

Question 19

Cyclosporine

Answer 19

MAO: calcineurin inhibitor, blocks NFAT, and thus blocks IL-2 release
Indications: organ transplantation, autoimmune disease
Toxicity: renal dysfunction, hypertension, diabetes

Question 20

Tacromilus

Answer 20

MAO: calcineurin inhibitor, NFAT block, IL-2 block
Indications: transplantation, autoimmune disease
Toxicity: renal dysfunction, hypertension, diabetes

Question 21

Methotrexate

Answer 21

MAO: blocks AICAR, increases adenosine, decreases inflammation and chemotaxis and cytokine release
Indications: first line for RA
Toxicity: hepatotoxicity, nausea, ulcers, cytopenia

Question 22

Azathiopurine

Answer 22

MAO: blocks DNA, RNA synthesis by being a prodrug for mercaptopurine
Indications: RA, transplantation
Toxicity: anorexia, poor wound healing, risk of bleeding

Inactivated by xanthine oxidase

Question 23

MMF

Answer 23

MAO: blocks DNA, RNA synthesis of purine nuclotides by being an antagonist for IMD which is needed to cause dna and rna synthesis.
Indications: transplantation
Toxicity: GI disturbance

Question 24

Cyclophosphamide

Answer 24

MAO: interferes with CD80 ligand and CD80 to disrupt activation of T cells Indications: RA Toxicity: none

Question 25

Aspirin

Answer 25

MAO: cox 1 and cox 2 inhibitor, decrease vessel sensitivity to histamine and bradykinin. Decrease IL-1 production. Indications: anti inflammatory, anti pyretic, blood thinner Toxicity: tinnitus, hypertension, abdominal pain, gastric ulcers, increased alveolar ventilation, hyperkalemia, renal failure, liver failure

Question 26

Diclofenac

Answer 26

MAO: cox 1 and cox 2 inhibitor, decrease vessel sensitivity to histamine and bradykinin. Decrease IL-1 production. Indications: anti inflammatory, anti pyretic, blood thinner Toxicity: tinnitus, hypertension, abdominal pain, gastric ulcers, increased alveolar ventilation, hyperkalemia, renal failure, liver failure

Question 27

Indomethacin

Answer 27

MAO: cox 1 and cox 2 inhibitor, decrease vessel sensitivity to histamine and bradykinin. Decrease IL-1 production. Indications: anti inflammatory, anti pyretic, blood thinner Toxicity: tinnitus, hypertension, abdominal pain, gastric ulcers, increased alveolar ventilation, hyperkalemia, renal failure, liver failure

Question 28

Ibuprofen

Answer 28

MAO: cox 1 and cox 2 inhibitor, decrease vessel sensitivity to histamine and bradykinin. Decrease IL-1 production. Indications: anti inflammatory, anti pyretic, blood thinner Toxicity: tinnitus, hypertension, abdominal pain, gastric ulcers, increased alveolar ventilation, hyperkalemia, renal failure, liver failure

Question 29

Naproxen

Answer 29

MAO: cox 1 and cox 2 inhibitor, decrease vessel sensitivity to histamine and bradykinin. Decrease IL-1 production. Indications: anti inflammatory, anti pyretic, blood thinner Toxicity: tinnitus, hypertension, abdominal pain, gastric ulcers, increased alveolar ventilation, hyperkalemia, renal failure, liver failure

Question 30

Celecoxib

Answer 30

MOA: selective cox2 inhibitor, blocks inflammation Indication: RA. Not cardio protective because not a cox1 inhibitor Toxicity: may interfere with warfarin

Question 31

Acetaminophen

Answer 31

MOA: cox3 inhibitor Indication: anti pyretic, analgesic, not anti inflammatory, used in RA Toxicity: renal failure, liver failure