anti-inflammatories

Question 1

Name some products of the COX pathway, describe differences between COX1 and COX2.

Answer 1

• COX = membrane protein with enzyme sites
• produces inflammatory mediators - prostaglandins and thromboxanes
• COX1
  
  • constant prostaglandin production, homeostasis
• COX2
  
  • inducible enzyme in response to injury and inflammation

Question 2

Name several NSAIDS, their mechanism of action and uses

Answer 2

NSAIDS:
- ASPIRIN
- binds to Ser residue in COX preventing arachadonic acid from reaching COX site
- anti-inflammatory, analgesic (pain), antipyretic (temp)
- IBUPROFEN
- non-selective, reversible inhibition of the cyclooxygenase enzymes COX-1 and COX-2
- NAPROXEN
- nonselective inhibitor of COX-1 and COX-2

Question 3

what are NSAIDS

Answer 3

Non-steroidal anti-inflammatory drugs (NSAIDs) are medicines that are widely used to relieve pain, reduce inflammation, and bring down a high temperature
= inhibit COX1 and COX2

Question 4

what are COXIBS

Answer 4

type of NSAIDS = COX-2 inhibitors

Question 5

Name several COXIBS, their mechanism of action and uses

Answer 5

Rofecoxib
celecoxib
Valdecoxib
Lumiracoxib
-> COX2 inhibitors
-> treats rheumatoid arthritis