Anti-infectives Drug Classes

Question 1

Which drug class?: PCN G & PCN VK

Answer 1

Beta-lactam penicillins, narrow-spectrum, beta-lactamase sensitive 1st generation

Question 2

Which drug class?: Dicloxacillin, oxacillin, nafcillin

Answer 2

Beta-lactam penicillins, narrow-spectrum, beta-lactamase resistant 2nd generation

Question 3

Which drug class?: Amoxicillin, ampicillin

Answer 3

Beta-lactam penicillins, extended-spectrum aminopenicillins, 3rd generation

Question 4

Which drug class?: Ticarcillin

Answer 4

Beta-lactam penicillin, extended-spectrum carboxypenicillin, 4th generation

Question 5

Which drug class?: Piperacillin

Answer 5

Beta-lactam penicillin, extended-spectrum ureidopenicillin, 5th generation

Question 6

Which drug class?: Ertapenem

Answer 6

Beta-lactam carbapenem, NO antipseudomonal activity

Question 7

Which drug class?: Doripenem, Imipenem, Meropenem

Answer 7

Beta-lactam carbapenem, antipseudomonal

Question 8

Which drug class?: Cefazolin, cephalexin, cefadroxil

Answer 8

Beta-lactam cephalosporins, 1st generation

Question 9

Which drug class?: Cefaclor, cefuroxime, cefoxitin

Answer 9

Beta-lactam cephalosporins, 2nd generation

Question 10

Which drug class?: Ceftriaxone, cefotaxime, cefdinir, cefpodoxime

Answer 10

Beta-lactam cephalosporins, 3rd generation, NO antipseudomonal activity

Question 11

Which drug class?: Ceftazidime

Answer 11

Beta-lactam cephalosporin, 3rd generation, antipseudomonal

Question 12

Which drug class?: Cefepime

Answer 12

Beta-lactam cephalosporin, 4th generation

Question 13

Which drug class?: Ceftaroline, ceftolozane

Answer 13

Beta-lactam cephalosporins, 5th generation

Question 14

Which drug class?: Cefiderocol

Answer 14

Beta-lactam cephalosporin, siderophore (hijacks bacterial iron-transport system)

Question 15

Which drug class?: Aztreonam

Answer 15

Beta-lactam cephalosporin, monobactam

Question 16

Which drug class?: Sulbactam, tazobactam, clavulanic acid, avibactam, durlobactam, vaborbactam

Answer 16

Beta-lactamase inhibitors

Question 17

Which drug class?: Vancomycin, telavancin, dalbavancin

Answer 17

Cell wall inhibitor, polypeptide, glycopeptides

Question 18

Which drug class?: Daptomycin

Answer 18

Cell wall inhibitor, polypeptide, lipopeptide

Question 19

Which drug class?: Colistin, polymyxin B

Answer 19

Cell wall inhibitors, polypeptides, polymyxins

Question 20

Which drug class?: Fosfomycin

Answer 20

Cell wall inhibitor, intracellular

Question 21

Which drug class?: Isoniazid

Answer 21

Cell wall inhibitor, lysozyme

Question 22

Which drug class?: Linezolid

Answer 22

Protein synthesis inhibitor, 50S inhibitor, oxazolidinone (initiation inhibitor)

Question 23

Which drug class?: Amikacin, tobramycin, neomycin

Answer 23

Protein synthesis inhibitors, 30S inhibitors, aminoglycosides (initiation inhibitors), Streptomyces-derived

Question 24

Which drug class?: Doxycycline, tetracycline

Answer 24

Protein synthesis inhibitors, 30S inhibitors, tetracyclines (tRNA binding)

Question 25

Which drug class?: Chloramphenicol

Answer 25

Protein synthesis inhibitor, 50S inhibitor, peptidyl transferase inhibitor, amphenicol

Question 26

Which drug class?: Erythromycin, azithromycin, clarithromycin

Answer 26

Protein synthesis inhibitors, 50S inhibitors, transpeptidation/translocation inhibitors, macrolides

Question 27

Which drug class?: Quinupristin/dalfopristin

Answer 27

Protein synthesis inhibitors, 50S inhibitors, transpeptidation/translocation inhibitors, streptogramins

Question 28

Which drug class?: Clindamycin

Answer 28

Protein synthesis inhibitor, 50S inhibitor, transpeptidation/translocation inhibitor, lincosamide

Question 29

Which drug class?: Gentamicin

Answer 29

Protein synthesis inhibitor, 30S inhibitor, aminoglycoside (initiation inhibitor), Micromonospora-derived

Question 30

Which drug class?: Tigecycline

Answer 30

Protein synthesis inhibitor, 30S inhibitor, tetracycline (tRNA binding), glycylcycline

Question 31

Which drug class?: Trimethoprim

Answer 31

Nucleic acid inhibitor, antifolate (purine metabolism inhibitor), dihydrofolate reductase inhibitor

Question 32

Which drug class?: Sulfamethoxazole

Answer 32

Nucleic acid inhibitor, antifolate (purine metabolism inhibitor), sulfonamide (dihydropteroate synthase inhibitor), intermediate-acting

Question 33

Which drug class?: Dapsone

Answer 33

Nucleic acid inhibitor, antifolate (purine metabolism inhibitor), dihydropteroate synthase inhibitor

Question 34

What drug class?: Ciprofloxacin, ofloxacin

Answer 34

Nucleic acid inhibitor, quinolone, fluoroquinolone, 2nd generation

Question 35

What drug class?: Levofloxacin

Answer 35

Nucleic acid inhibitor, quinolone, fluoroquinolone, 3rd generation

Question 36

What drug class?: Moxifloxacin

Answer 36

Nucleic acid inhibitor, quinolone, fluoroquinolone, 4th generation

Question 37

What drug class?: Metronidazole

Answer 37

Nucleic acid inhibitor, anaerobic DNA inhibitor, nitroimidazole derivative

Question 38

What drug class?: Nitrofurantoin

Answer 38

Nucleic acid inhibitor, anaerobic DNA inhibitor, nitrofuran derivative

Question 39

What drug class?: Rifampin [rifampicin]

Answer 39

Nucleic acid inhibitor, RNA synthesis inhibitor, rifamycin

Question 40

What drug class?: Fidaxomicin

Answer 40

Nucleic acid inhibitor, RNA synthesis inhibitor, lipiarmycin

Question 41

What drug class?: Mupirocin

Answer 41

Protein synthesis inhibitor, tRNA synthetase inhibitor, pseudomonic acid mixture