Anti - infective Drugs (Antibiotics, Antitubercular)

Question 1

anti-metabolites; inhibit growth by preventing bacterial synthesis of folic acid

Answer 1

Sulfonamides

Question 2

combined with erythromycin

Answer 2

Sulfisoxazole

Question 3

Active against Pseudomonas and relatively ineffective

against gram-positive organisms

Answer 3

Extended-spectrum penicillin

Question 4

Nursing Intervention: Allergy skin testing

Answer 4

Penicillin

Question 5

Drug of choice for Legionnaires CAMP (Legionnella, Campylobacter, Mycoplasma, Bordetella )

Answer 5

Erythromycin (Macrolides)

Question 6

Nursing Responsibility: Do not give with fruit juice

Answer 6

Macrolides

Question 7

Gram (-) and some gram (+) UTI and respiratory tract infections

Answer 7

Quinolones

Question 8

examples: Ciprofloxacin, levofloxacin, moxifloxacin (-xacin)

Answer 8

Quinolones

Question 9

Drug Interaction: Anti Vitamin K (bleeding tendencies)

Answer 9

Cephalosporins

Question 10

treatment and prophylaxis

of infections in hospitalized patients

Answer 10

3rd generation Cephalosporins

Question 11

designed to target organisms with multiple drug resistance

Answer 11

4th generation Cephalosporins

Question 12

For serious gram (+) & (-) infections; Therapeutic Goal - below or at 1 mcg/mL trough level

Answer 12

Aminoglycosides

Question 13

Nursing Intervention: baseline hearing

Answer 13

Aminoglycosides

Question 14

Drug of Choice for chlamydia, mycoplasma, rickettsia, H. pylori, cholera, shigellosis

Answer 14

Tetracyclines

Question 15

Nursing Responsibility: Remind to avoid sun exposure and tanning bed use
(photosensitivity)

Answer 15

Tetracyclines

Question 16

Drug of Choice for pseudomonas, UTI, systemic infections; Aztreonam

Answer 16

Monobactam

Question 17

broadest activity beta-lactam: reserved for complicated body cavity and connective tissue infections; Meropenem, Ertapenem, Doripenem (-penem)

Answer 17

Carbapenem

Question 18

Nursing responsibility: Must be infused over 60 min

Answer 18

Carbapenem

Question 19

Better to be used only topically

Answer 19

VANCOMYCIN and BACITRACIN

Question 20

Penetrates most tissues including bone; Effective against anaerobes

Answer 20

CLINDAMYCIN

Question 21

Reserved for life-threatening infections d/t serious side effects(bone marrow depression, aplastic anemia [fatal]; gray baby syndrome)

Answer 21

CHLORAMPHENICOL

Question 22

Nursing responsibility: Use sunblock to TAN!

Answer 22

Tetracyclines, Aminoglycosides, NSAIDS

TAN

Question 23

Nursing responsibility: Assess for tinnitus

Answer 23

Erythromycin and Aminoglycosides (EAr)

Question 24

Nursing responsibility: No TeA for children!

Answer 24

Tetracyclines and Aspirin

TeA

Question 25

Rifampin, Isoniazid, Pyrazinamid, Ethambutol, Streptomycin

Answer 25

Anti-tubercular drugs (RIPES)

Question 26

MORE effective and LESS toxic than second-line

Answer 26

First Line Antitubercular Drugs (Isoniazid, Streptomycin, Rifampin, Ethambutol)

Question 27

most frequently prescribed regimen for uncomplicated pulmonary TB; red-orange color to body fluids (urine, sweat, saliva, tears)

Answer 27

Rifampin + isoniazid

Question 28

Primary agent for treatment and prophylaxis of TB

Answer 28

Isoniazid

Question 29

A bactericidal to M. tuberculosis; MOST hepatotoxic of all 1st line drugs - high dose therapy may cause hepatitis, fatal hepatic necrosis

Answer 29

Pyrazinamide

Question 30

preferred regimen for initial therapy of active disease caused by drug-sensitive M. tuberculosis

Answer 30

Rifampin + Isoniazid + Pyrazinamide + Ethambutol