Anti-Infective Agents Flashcards
Zovirax
Generic Name: acyclovir
Class: Viral DNA Polymerase Inhibitor
Uses: genital herpes simplex, varicella (chickenpox), cold sores
MOA: it is a acyclic nucleoside analogue of deoxyguanosine that is selectively phosphorylated by the virus-encoded thymidine kinase to its monophosphate form
Normal Daily Dose: genital herpes ( 400 mg po tid or 200 mg po 5 times a day for 7-10 days)
Metabolism: not metabolized
Albenza
Generic Name: albendazole
Class: Anthelmintic
Uses: parenchymal neurocysticercosis by Taenia solium, cystic hydratid disease of the liver, lung, and peritoneum
MOA: selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae. This leads to impaired glucose uptake in parasites and ATP production decreases leading to energy depletion and death
Normal Daily Dose: adult>60kg: 400 mg bid with meals for 8-30 days;
adults and children <60kg: 15mg/kg/d in 2 divided doses for 8-30 days
Metabolism: Hepatic to 1 active metabolite; minor substrate of CYP3A4/5/1A2
Amoxil, Moxatag
Generic Name: amoxicillin
Class: Beta-Lactam Antibiotic
Uses: acute otitis media, lower respiratory tract infection, pharyngitis, tonsillitis, streptococcal pharyngitis, ear, nose, and throat infection, H.pylori tract infection
MOA: Semisynthetic penicillin derivative that inhibits the biosynthesis of bacterial cell wall mucopeptide. Typically active against Streptococcus, Enterococcus, Staphylococcus, and Enterobacteriaceae
Normal Daily Dose:
adults: 500 mg po bid or 1 g po daily x 10 d; children: 50mg/kg po once a daily for 10 d, max 1 g daily
Metabolism: partially hepatic
Augmentin
Generic Name: amoxicillin/clavulanate
Class: Beta-Lactam Antibiotic
Uses: Acute otitis media, community acquired pneumonia, lower respiratory tract infection, sinusitis, urinary tract infection, acute cystitis, pyelonephritis
MOA: a semisynthetic penicillin,
Normal Daily Dose: urinary tract infection: 500 mg bid x 5-7 d; acute otitis media: adults- 500-875 mg po q12h x 10 d children- 80-90 mg/kg/d po in 2-3 divided doses; lower respiratory tract infection: 1000 mg po tid x 10 d
Metabolism: Amoxicillin not metabolized, extensive metabolism of clavulanic acid
Atazanavir
Generic Name: reyataz
Class: antiretroviral agent, protease inhibitor
Uses: treatment of HIV-1 infection
MOA: binds to the site of HIV-1 protease activity and inhibits cleavage of viral Gag-Pol polyprotein precursors into individual functional proteins required for infectious HIV. This results in the formation of immature, noninfectious viral particles
Normal Daily Dose: adults and children>13 y of age and >40 kg, 300 mg po with ritonavir 100 mg or cobicistat 150 mg; adults unable to tolerate ritonavir, atazanavir 400 mg d
Metabolism: Hepatic substrate of CYP3A4/5, strong inhibitor of CYP3Q4/5 and UGT1A1
Zithromax, Z-Pak
Generic Name: azithromycin
Class: macrolide antibiotic
Uses: acute infective exacerbation of COPD, skin or tissue infection; bacterial sinusitis, chancroid nongonococcal cervicitis/urethritis; community-acquired pneumonia, sexually transmitted infections, streptococcal pharyngitis
MOA: it is slightly less active than erythromycin against gram-positive bacteria; azithromycin binds to the 50S ribosomal subunit, thus interfering with microbial protein synthesis
Normal Daily Dose:
active infective exacerbation of COPD, skin, or tissue: 500 mg po daily x 3 d; STIs: 1-2 g po x 1 dose; streptococcal pharyngitis: 500 mg po x 1 dose, then 250 mg po daily x 2-5 d;
Metabolism: renal 6% with a half-life of 68 h
Omnicef
Generic Name: cefdinir
Class: third-generation cephalosporin
Uses: acute otitis media, pharyngitis, tonsilitis, bronchitis, community-acquired pneumonia, bronchitis, COPD/acute exacerbation, streptococcal pharyngitis, group A
MOA: activity against a number of gram-positive and gram-negative bacteria including Beta-lactamase- producing strains
Normal Daily Dose: 300 mg po bid x 5-10 d
Metabolism: not metabolized
Ceftin, Zinacef
Generic Name: cefuroxime
Class: second-generation cephalosporin
Uses: acute infective exacerbation of COPD; acute otitis media, bronchitis, secondary bacterial infection, gonorrhea, pharyngitis, tonsilitis, UTI, bite wound, prophylaxis or treatment
MOA: Beta-lactamase- producing strains
Normal Daily Dose: 250-500 mg po bid x 10 d
Metabolism: Cefuroxime is rapidly hydrolyzed by plasma and GI esterases
Keflex
Generic Name: cephalexin
Class: first-generation cephalosporin
Uses: infection of skin and/or subcutaneous tissue, osteomyelitis, otitis media, respiratory tract infection, UTI, streptococcal pharyngitis, impetigo, cellulitis
MOA: inhibits bacterial wall synthesis of actively dividing cells by binding to >1 penicillin-binding proteins
Normal Daily Dose: 25-500 mg q12h
Metabolism: not metabolized
Peridex, Paroex, Hibiclens, Periogard
Generic Name: chlorhexidine
Class: antibacterial cleansing agent
Uses: gingivitis, skin or wound cleansing, periodontitis
MOA: it is an antiseptic and antimicrobial drug with bactericidal activity; has activity against gram-positive and gram-negative organisms, facultative anaerobes, aerobes, and yeast. It is both bacteriostatic and bactericidal, depending on its concentration
Normal Daily Dose: 15 mL oral rinse, swish 30 s and spit bid
Metabolism: Not absorbed
Cipro
Generic Name: ciprofloxacin
Class: fluoroquinolone
Uses: anthrax, postexposure prophylaxis, bacterial prostatitis, bronchitis, lower respiratory tract infection, UTI
MOA: inhibits bacterial DNA gyrase; it is highly active against aerobic, gram-negative bacilli
Normal Daily Dose: 500 mg po q12
Metabolism: not metabolized; substrate of P-glycoprotein; strong inhibitor of CYP1A2
Cetraxal, Otiprio,
Generic Name: ciprofloxacin otic
Class: fluoroquinolone
Uses: otitis externa, otitis media with effusion
MOA: inhibits bacterial DNA gyrase, it is highly active against aerobic, gram-negative bacilli
Normal Daily Dose: 0.1-0.25 mL into affected ear(s) bid x 7 d
Metabolism: Not systemically absorbed
Biaxin
Generic Name: clarithromycin
Class: macrolide antibiotic
Uses: acute infective exacerbation of bronchitis, community-acquired pneumonia, H.pylori tract infection, streptococcal pharyngitis, COPD
MOA: binds to the 50S ribosomal subunit of the 70S ribosomes of susceptible organisms, thereby inhibiting bacterial RNA-dependent protein synthesis
Normal Daily Dose: 250500 mg po bid x 7-14 d
Metabolism: Hepatic substrate of CYP3A4/5 inhibitor of CYP3A4/5, P-glycoprotein
Cleocin
Generic Name: clindamycin
Class: lincosamide antibiotic
Uses: bacterial infectious disease, infection of skin and/or subcutaneous tissue, infectious disease of abdomen, lower respiratory tract infection, pelvic inflammatory disease, septicemia, osteomyelitis, diabetic foot infection, bacterial vaginosis
MOA: is a semisynthetic 7-chloro-deoxylincomycin derivative that is active against most-positive organisms except enterococci and C. difficile. Gram-negative aerobes are resistant, but most anaerobes are sensitive. It inhibits bacterial protein synthesis by binding the 50S ribosomal subunit; it is bactericidal or bacteriostatic depending on the concentration, organism, and inoculums
Normal Daily Dose: 150-450 mg po q6h
Metabolism: minor hepatic via CYP3A4/5
Cleocin T, Clindagel, Clindesse, Evoclin
Generic Name: clindamycin topical
Class: lincosamide antibiotic
Uses: acne vulgaris, bacterial vaginosis
MOA: It inhibits bacterial protein synthesis by binding the 50S ribosomal subunit; it is bactericidal or bacteriostatic depending on the concentration, organism, and inoculums
Normal Daily Dose: acne vulgaris: apply thin-film bid to affected area; bacterial vaginosis-suppositories, 100 mg daily intravaginally hs x 3 d
Metabolism: Not systemically absorbed
Adacel, Boostrix, Daptacel, Infanrix, Tenivac
Generic Name: Diphtheria Toxoid
Class: Vaccine, Inactivated, Bacterial
Uses: Prevention of diphtheria
MOA: n/a
Normal Daily Doses: primary series of DTaP all infants at 2.4. 6 mo of age (repeated q4-8wk x 3 doses). 4th dose at 15-18 mo of age (>6 mo since 3rd dose, as early as 12 mo of age); 5th dose at 4-6 y of age; booster of Tdap at 11-12 y of age; adults and children >7 y of age, Td every 10 y if primary series completed
Metabolism: n/a
Vibramycin, Doxy 100
Generic Name: doxycycline
Class: tetracycline antibiotic
Uses: acinetobacter infection, acne vulgaris, gonorrhea, staphylococcal infection, pneumonia
MOA: a broad-spectrum bacteriostatic compound that inhibits protein synthesis at the 30S ribosomal subunit.
Normal Daily Doses: 100 mg po q12 h on day 1, then 100 mg po bid x 7 d or 300 mg po single dose
Metabolism: Hepatic 50%
Sustiva
Generic Name: efavirenz
Class: antiretroviral agent, reverse transcriptase inhibitor
Uses: treatment of HIV-1 infection
MOA: binds to HIV reverse transcriptase, blocking the RNA-dependent and DNA-dependent DNA polymerase activities including HIV-1 replication
Normal Daily Doses: 600 mg po daily hs
Metabolism: Hepatic substrate of via CYP3A4/5. 2B6; inhibits CYP2C9 and 2C19; induces CYP3A4/5
Truvada
Generic Name: emtricitabine/ tenofovir disoproxil
Class: antiretroviral agent, reverse transcriptase inhibitor
Uses: treatment of HIV-1 infection
MOA: emtricitabine is a cytidine analogue while tenofovir is an analogue of adenosine 5’-monophosphate. Each drug interferes with HIV viral RNA-dependent DNA polymerase resulting in inhibition of viral replication
Normal Daily Doses: emtricitabine/tenofovir 200mg/300mg po daily
Metabolism: minimal; tenofovir induces P-gp
Baraclude
Generic Name: entecavir
Class: antiretroviral agent, reverse transcriptase inhibitor
Uses: treatment of chronic HBV infection
MOA: intracellularly phosphorylated to guanosine triphosphate which competes with natural substrates to effectively inhibit HBV polymerase; enzyme inhibition blocks reverse transcriptase activity thereby reducing viral DNA synthesis
Normal Daily Doses: 0.5-1 mg po daily
Metabolism: not metabolized
Dificid
Generic Name: fidaxomicin
Class: macrolide antibiotic
Uses: D. difficile infection
MOA: antibacterial agent that acts locally in the GI tract on C. difficile via inhibition of RNA polymerases
Normal Daily Doses: 300 mg po bid x 10 d
Metabolism: intestinal hydrolysis to less active metabolite (OP-1118)
Diflucan
Generic Name: fluconazole
Class: imidazole antifungal
Uses: candidal vulvovaginitis, candidiasis, cryptococcal meningitis, oropharyngeal candidiasis
MOA: inhibits biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and altering its permeability
Normal Daily Doses: 150 mg po x 7-14 d
Metabolism: minimal metabolism, but moderate inhibitor of CYP2C9,3A4/5 and strong inhibitor of CYP2C19
Zymaxid
Generic Name: gatifloxacin ophthalmic
Class: fluoroquinolone antibiotic
Uses: bacterial conjunctivitis
MOA: inhibits bacterial DNA gyrase and topoisomerase IV. It is highly active against aerobic, gram-negative bacilli
Normal Daily Doses: 1 drop to affected eye(s) q2h while awake on day 1, then qid while awake for 6 more d
Metabolism: Not absorbed
Hiberix, PedvaxHIB, ActHIB
Generic Name: haemophilus influenzae, type B vaccine
Class: vaccine, inactivated, bacterial
Uses: prevention of invasive H. influenzae type b infection
MOA: n/a
Normal Daily Doses:
ActHIB doses at 2,4,6 and 12-15 mo of age primary series
PedvaxHIB doses: 2,4, and 12-15 mo are used
Hiberix: can be used only for the last dose for children 12 mo to 4 y of age
Metabolism: n/a
Havrix, Vaqta
Generic Name: hepatitis a vaccine
Class: vaccine, inactivated, viral
Uses: hepatitis a prophylaxis
MOA: n/a
Normal Daily Doses: inject units IM once, with a 2nd dose 6-12 months later, or Vaqta 50 units IM once, with a 2nd dose 6-18 mo later; children 12 mo to 18 y
Metabolism: n/a
Engerix-B, Recombivax HB
Generic Name: hepatitis b vaccine
Class: vaccine, inactivated, viral
Uses: prevention of hepatitis b infection
MOA: n/a
Normal Daily Doses: Engerix 20 mcg IM or Recombivax 10 mcg IM given once, with 2 additional doses given 1 and 5 mo later
Metabolism: n/a
Gardasil 9
Generic Name: human papillomavirus vaccine
Class: vaccine, inactivated, viral
Uses: prevention of human papillomavirus infection, cancer and precancerous lesions of the cervix, vulva, vagina, and anus and genital warts
MOA: n/a
Normal Daily Doses: 0.5 mL at 0,2, and 6 mo; children >9 y of age and <15 y of age, 2 dose series, 0.5 mL, AT 0 AND 6-12 mo
Metabolism: n/a
Plaquenil
Generic Name: hydroxychloroquine
Class: aminoquinoline
Uses: lupus, malaria, rheumatoid arthritis
MOA: unknown
Normal Daily Doses: 200-400 mg po daily
Metabolism: 40% and occurs by unknown enzymes
Zyclara, Aldara
Generic Name: Imiquimod
Class: immune response modifier
Uses: actinic keratosis, condyloma acuminatum, superficial basal cell carcinoma
MOA: toll-like receptor 7 agonist that induces cytokines, including interferon-alpha and others
Normal Daily Doses: apply topically to affected treatment area once daily at bedtime for 2 wk, followed by 2 wk of no treatment and repeat for another 2 wk; apply topically once daily 5 times per wk x 6 wk
Metabolism: unknown
Alfuria, Fluad, Flublok, Fluzone, FluLaval, Fluarix
Generic Name: influenza virus vaccine
Class: vaccine, inactivated, viral
Uses: prevention of influenza infection
MOA: n/a
Normal Daily Doses:
Metabolism: n/a
Nizoral
Generic Name: ketoconazole
Class: imidazole antifungal
Uses: candidiasis of skin, dandruff, pityriasis versicolor, seborrheic dermatitis, tinea corporis, tinea cruris, tinea pedis
MOA: inhibits biosynthesis of ergosterol or other sterols, damaging the fungal cell wall membrane and altering its permeability
Normal Daily Doses: apply topically once daily for 2 wk
Metabolism: minimal absorption
Levaquin
Generic Name: levofloxacin
Class: fluoroquinolone antibiotic
Uses: bacterial prostatitis, bacterial sinusitis, bronchitis, chronic, acute bacterial exacerbation, community acquired pneumonia, infection of skin and/or subcutaneous tissue, pyelonephritis
MOA: inhibits bacterial DAN gyrase, an enzyme responsible for the unwinding of DNA for transcription and subsequent supercoiling of DNA for packaging into chromosomal subunits. It is highly active against aerobic, gram-negative bacilli
Normal Daily Doses: 500-750 mg daily x 7 d
Metabolism: not metabolized
Selzentry
Generic Name: maraviroc
Class: antiretroviral agent, CCR5 antagonist
Uses: treatment of CCR5-tropic HIV-1 infection
MOA: selectively and reversibly binds to the chemkine receptor coreceptors located on human CD4 cells.
Normal Daily Doses: 300 mg po bid
Metabolism: hepatic CYP3A4/5
M-M-R II
Generic Name: measles, mumps, rubella vaccine
Class: vaccine, live, viral
Uses: prevention of measles, mumps, and rubella infection
MOA: n/a
Normal Daily Doses: 1 dose indicated for adults born after 1957; children, 1 dose at 12-15 mo of age with a 2nd dose at 406 y of age, prior to entering school
Metabolism: n/a
Menactra, Menveo Trumenba, Bexsero
Generic Name: Meningococcal vaccine
Class: vaccine, inactivated, bacterial
Uses: prevention of invasive meningococcal disease caused by serotypes A, C, Y, W-135
MOA: n/a
Normal Daily Doses:
Metabolism: n/a
Flagyl
Generic Name: metronidazole
Class: nitroimidazole antibiotic, antiprotozoal
Uses: abscess, amebic dysentery, bacterial vaginosis, trichomoniasis
MOA: synthetic nitroimidazole; it is a bactericidal against nearly all obligate anaerobic bacteria
Normal Daily Doses: 500 mg po bid x 7 d
Metabolism: hepatic 30-60% via glucuronidation; moderate CYP3A4/5 inhibitor
Minocin
Generic Name: minocycline
Class: tetracycline antibiotic
Uses: acne vulgaris, bacterial infectious disease
MOA: inhibit protein synthesis at the 30S ribosomal subunit
Normal Daily Doses: single 200 mg loading dose, then 100 mg bid
Metabolism: hepatically metabolized. extent unknown
Avelox
Generic Name: moxifloxacin
Class: fluoroquinolone antibiotic
Uses: acute bacterial exacerbation of chronic bronchitis, bacterial sinusitis, community-acquired pneumonia, infection of skin and/or sq tissue, complicated intra-abdominal infections
MOA: inhibits bacterial topoisomerase II and IV
Normal Daily Doses: 400 mg po daily
Metabolism: 52% hepatic via glucuronide and sulfate conjugation
Vigamox, Moxeza
Generic Name: Moxifloxacin Ophthalmic
Class: fluoroquinolone antibiotic, ophthalmic
Uses: bacterial conjunctivitis
MOA: inhibits bacterial topoisomerase II and IV
Normal Daily Doses: 1 drop to affected eye(s) bid (moxeza) or tid (vigamox) x 7 d
Metabolism: not absorbed
Bactroban
Generic Name: mupirocin
Class: topical antibacterial
Uses: impetigo, secondary skin infection, eradication of nasal colonization of MRS during institutional outbreaks
MOA: antibacterial agent active against a wide range of gram-positive bacteria including methicillin-resistant Staphylococcus aureus
Normal Daily Doses: apply topically tid x 3-5 d
Metabolism: not absorbed
Alinia
Generic Name: nitazoxanide
Class: antiprotozoal
Uses: diarrhea caused by C. parvum or G. lamblia
MOA: interference with the pyruvate: ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic metabolism of protozoans
Normal Daily Doses: 100-200 mg q12h x 3 d
Metabolism: metabolized to 1 active metabolite by plasma esterases
Macrobid, Macrodantin
Generic Name: nitrofurantoin
Class: nitrofuran antibiotic
Uses: urinary tract infections
MOA: inactivates bacterial ribosomes and is bactericidal in urine at therapeutic doses
Normal Daily Doses: 100 mg po bid x 5-7 d
Metabolism: metabolism in all tissues to inactive metabolite
Bio-Statin
Generic Name: nystatin systemic
Class: polyene antifungal
Uses: GI candidiasis, oropharyngeal candidiasis
MOA: binds to the sterols in fungal cell walls, damaging the fungal cell wall membrane and altering its permeability for leakage of cellular contents
Normal Daily Doses: 500,000-1,000,000 units po tid
Metabolism: minimal absorption
Nystop, Mycostatin, Nyamyc
Generic Name: Nystatin topical
Class: polyene antifungal
Uses: candidiasis of skin
MOA: binds to the sterols in fungal cell walls, damaging the fungal cell wall membrane and altering its permeability allowing for leakage of cellular contents
Normal Daily Doses: apply liberally to affected areas topically bid-tid until healing complete
Metabolism: not absorbed
Tamiflu
Generic Name: oseltamivir
Class: neuraminidase inhibitor, antiviral
Uses: influenza virus types A and B
MOA: inhibitor of influenza virus neuraminidase which prevents viral progeny detaching from the cellular envelope
Normal Daily Doses:
Metabolism: oseltamivir phosphate is a prodrug that is extensively metabolized to oseltamivir carboxylate by ester hydrolysis
Penicillin
Generic Name:
Class: antibiotic
Uses: bacterial endocarditis, otitis media, streptococcal pharyngitis, erysipelas, mild infection or step down therapy
MOA: active against most gram-positive organisms and some gram-negative organisms
Normal Daily Doses: 250-500 mg po q6h
Metabolism: not metabolized
Daptacel, Adacel, Boostrix, Infanrix
Generic Name: pertussis
Class: vaccine, inactivated, bacterial
Uses: prevention of pertussis
MOA: n/a
Normal Daily Dose: children, all infants at age 2,4,6 and 12-15 mo, and a 5th dose at age 4-6 y, as primary series of DTaP; DTaP at age 11-12 y; single dose of Tdap for all adults at next opportunity
Metabolism: n/a
Prevnar13, Pneumovax23, Vaxneuvance, Prevnar 20
Generic Name: Pneumococcal vaccine
Class: vaccine, inactivated, bacterial
Uses: prevention of invasive pneumococcal disease
MOA: n/a
Normal Daily Dose: adults >65 y of age: single dose 0.5 mL IM; children: single dose 0.5 mL IM at 2,4,6, and 12-15 mo of age as primary series
Metabolism: n/a
Ipol
Generic Name: poliovirus
Class: vaccine, inactivated, viral
Uses: prevention of poliomyelitis
MOA: n/a
Normal Daily Dose: children: one 0.5mL IM or SC at 2,4, and 6-18 mo of age, and a booster at 4-6 y of age as primary series
Metabolism: n/a
Isentress
Generic Name: raltegravir
Class: antiretroviral agent, integrase inhibitor
Uses: treatment of HIV-1 infection in combination with other antiretroviral agents
MOA: inhibits the catalytic activity of HIV-1 integrase, thus preventing integration of viral DNA into the host strand
Normal Daily Dose: 400 mg po bid
Metabolism: via UGT1A1to an inactive metabolite
Rotarix, RotaTeq
Generic Name: rotavirus
Class: vaccine, live, viral
Uses: prophylaxis of viral gastroenteritis due to rotavirus infection
MOA: n/a
Normal Daily Dose:
Metabolism: n/a
Lamisil
Generic Name: terbinafine
Class: miscellaneous antifungals
Uses: treats infections caused by fungus that affect the fingernails or toenails
MOA: kills fungus by inhibiting the enzyme squalene epoxidase, which prevents the conversation of squalene to squalene oxide
Normal Daily Dose: 250 mg po once a day
Metabolism: hepatic pathway CYP2C9
Daptacel, Infanrix, Adacel, Boostrix
Generic Name: tetanus toxoid
Class: vaccine, inactivated, bacterial
Uses: prevention of tetanus
MOA: n/a
Normal Daily Dose: children, all infants at 2,4,6, and 12-15 mo of age, and a 5th dose at 4-6 y of age, as primary series of DTaP
Tdap every 10 y for adults and children >7 y of age
Metabolism: n/a
Bactrim, Septra
Generic Name: trimethoprim (TMP)/ sulfamethoxazole (SMZ)
Class: sulfonamide antibiotic
Uses: acute infective exacerbation of COPD; HIV infection, traveler’s diarrhea, UTI
MOA: SMZ: inhibits the synthesis of dihydropteroic acid
TMP: inhibits the enzymatic reduction of dihydro folic acid to tetrahydro folic acid
Normal Daily Dose: 800 mg SMZ and 160 mg TMP po bid x 10-14 d
Metabolism: hepatic metabolism >90%, TMP is CYP2C9 and CYP3A4/5 substrate; TMP is moderate inhibitor of CYP2C8 and CYP2C9
Valtrex
Generic Name: valacyclovir
Class: viral DNA polymerase inhibitor
Uses: genital herpes simplex; herpes zoster (shingles); varicella; herpes labialis (cold sores)
MOA: valacyclovir is a prodrug of acyclovir– acyclic nucleoside analogue of deoxyguanosine that is selectively phosphorylated by the virus-encoded thymidine kinase to its monophosphate form.
Normal Daily Dose: 1 g po bid
Metabolism: hepatic; rapidly and nearly completely to acyclovir and L-valine
Varivax
Generic Name: varicella
Class: vaccine, live, viral
Uses: prevention of varicella infection
MOA: n/a
Normal Daily Dose: adults: 2 doses separately by at least 4 wk; children: 1 dose at 12 mo of age with a 2nd >3 mo later
Metabolism: n/a
Shingrix
Generic Name: zooster
Class: vaccine, recombinant
Uses: prevention of herpes zoster (zoster, shingles)
MOA: n/a
Normal Daily Dose: adults: >50 y of age, 0.5 mL IM as a 2-dose with second dose between 2 and 6 mo after the first dose
Metabolism: n/a
