Anti-Hypertensives

Question 1

Thiazide diuretics

• types + doses
• MoA
• time for effect
• LT effect

Answer 1

Bendrofluazide (2.5mg od), chlorothalidone (12.5-25mg od),hydrochlorothiazide.
Inhibit NaCl in DCT causing mild diuresis/natriuresis, vasodilatory by opening vascular K channels.
Takes 8-12wks to see effect
LT - inhibits renal tubular reabsorption + reduce total body Na/H2O (reducing BP)

Question 2

What are the SEs of thiazide diuretics?

Answer 2

Diuresis
Erectile dysfunction
Reduce glucose tolerance + insulin sensitivity
Increases urate + exacerbates gout
Reduces K/Na/Mg

Question 3

Loop Diuretics

• Dose
• MoA
• Used for
• PDs

Answer 3

Frusemide 40mg od
Inhibits NKCC2 channel in TAL = potent diuretic
For severe/resistant HTN w/ ACEi
Steep dose-response curve

Question 4

What are the SEs for loop diuretics?

Answer 4

Dehydration
Polyuria
Reduced Na/K/Mg