Anti-hypercholesterolaemia drugs Flashcards
Give an example of a HMG-CoA reductase inhibitor?
Statins- e.g. Rosouvastatin
Describe the MAO of HMG-CoA reductase inhibitors?
What would changes would be seen in follow up Ix?
MA: inhibit conversion of HMG-CoA to mevalonate (cholesterol precursor)
Ix: decrease LDL, increase HDL, decrease TG
List SE of HMG-CoA reductase inhibitors?
SE: hepatotoxicity (increased LFTs), myopathy (esp. w fibrates or niacin)
Give an example of a cholesterol absorption inhibitor?
Ezetimibe
Describe the MAO of cholesterol absorption inhibitors?
What would changes would be seen in follow up Ix?
MA: prevent cholesterol absorption at SI brush border
Ix: decrease LDL
What is the MAO of bile acid resins?
What would changes would be seen in follow up Ix?
MA: prevent intestinal reabsorption of bile acids -> liver must use cholesterol to make more
Ix: decreased LDL, slight increase HDL, slight increase TG
List SE of bile acid resins?
SE: GI upset, decreased absorption of other drugs and fat-soluble vitamins
Give an example of a fibrate medication?
Gemfibrozil
Describe the MAO of fibrates?
What would changes would be seen in follow up Ix?
MA: upregulate LPL -> increase TG clearance, activates PRAR-a to induce HDL synthesis
Ix: decreased LDL, increased HDL, decreased TG
What are some SE of fibrates?
SE: myopathy (increased risk w statins), cholesterol gallstones
What is the MAO for Niacin?
What would changes would be seen in follow up Ix?
Vit B3
MA: inhibits lipolysis (hormone sensitive lipase) in adipose tissue, reduces hepatic VLDL synthesis
Ix: decrease LDL, increase HDL, decrease TG
What are some Niacin SE?
SE: red, flushed face (decreased by NSAIDs or LTM use), hyperglycaemia, hyperuricemia
