Anti-Glaucoma drugs-Fitz

Question 1

What anti-glucoma drug is known to inhibit aqueous humor secretion but it is also reported to increase uveoscleral outflow. it was also noted to be protective against loss of retinal ganglion cells.

Answer 1

Brimonidine - alpha 2 adrenoceptor agonist

Question 2

what carbonic anhydrase inhibitor was commercially available for inflow suppression to great glaucoma and works well with the eye pH

Answer 2

Dorzolamide

Question 3

_ is an outflow enhancer of ocular pressure and is used to treat glaucoma by lowering intraocular pressure by increasing pressure-dependent aqueous humor outflow via trabecular meshwork.

Answer 3

Picocarpine (M3 receptor agonist)

Question 4

_ receptor agonist lower intraocular pressure by enhacning uvoelscleral outflow. Causes remodeling of ciliary body with formation of partialy organized intermuscular tubes.

Answer 4

Postanoid FP receptor agonist such as fluprostenol

Question 5

How does acetazolamide lower intraocular pressure?

Answer 5

Carbonic anhydrase inhibitors. inhibits aqueous humor secretion

Question 6

How does apraclonidine lower intra-ocular pressure?

Answer 6

Agonist of alphae 2 adrenergic receptors

Question 7

Which adrenergic drugs used to treat glaucoma work by decreasing aqueous humor secretion from ciliary epithelium?

Answer 7

Timolol (beta adrenergic receptor antagonist)
Betaxolol (b1 selective cardioselctive = less risk in asthmatics)
Apraclonidine (a2 receptor agonists pre-synaptic)