Anti glaucoma drugs

Question 1

What is uveoscleral outflow?

Answer 1

Through spaces between bundles of ciliary muscle

Question 2

selectively increase uveoscleral outflow

Answer 2

prostanoid FP Receptor agonist

Question 3

Alters trabecular and uveoscleral outflow

Answer 3

bimatropost

Question 4

what inhibits aqueous humor secretion

Answer 4

adrenergic agents
B2-subject to desensitization
alpha (clonidine)–lots of SEs
brimonidine (alpha2)

Question 5

Brimonidine functions

Answer 5

alpha 2 agonist
inhibits aqueous humor secretion
increases uveoscleral outflow
protect against loss of retinal cells

Question 6

Beta adrenoceptor antagonists–most common drug? concerns?

Answer 6

Timolol

concern in patients with respiratory disease

Question 7

carbonic anhydrase inhibitors

Answer 7

• target the catalytic formation of HCO3 which is the driving force for aqueous humor secretion
• acetazolamide
• dorzolamide

Question 8

pilocarpine MOA

Answer 8

• increases P-dependent aqueous humor outflow via the trabecular meshwork
• M3 mACH mediated contraction of ciliary muscle–causes widening of trabecular meshwork spaces
• SEs–miosis, spasm of accommodation, brow ache

Question 9

prostanoid FP Receptor agonist

Answer 9

• latanoprost
• travoprost
• enhances uveoscleral outflow

Question 10

prostamide

Answer 10

• bimatropost–prostaglanding F2 analog

- enhances uveoscleral outflow

Question 11

B2 Adrenoceptor agonist–secretion, trabecular outflow, uveoscleral outflow

Answer 11

• secretion–decreases

- trabecular outflow increases

Question 12

B1 adrenoceptor antagonists–secretion, trabecular outflow, uveoscleral outflow

Answer 12

-secretion decreases

Question 13

alpha 2 adrenoceptor agonists–secretion, trabecular outflow, uveoscleral outflow

Answer 13

• decrease secretion

- increase uveoscleral outflow

Question 14

carbonic anhhydrase inhibitors–secretion, trabecular outflow, uveoscleral outflow

Answer 14

-decrease secretion

Question 15

muscarinic ACh R agonists–secretion, trabecular outflow, uveoscleral outflow

Answer 15

-increase trabecular outflow

Question 16

prostanoid FP Receptor agonists–secretion, trabecular outflow, uveoscleral outflow

Answer 16

-increase uveoscleral outflow

Question 17

prostamides–secretion, trabecular outflow, uveoscleral outflow

Answer 17

• trabecular outflow-increases

- uveoscleral outflow-increases