Anti-Fungal Agents Flashcards
Which Anti-Fungal drugs have good oral bioavailability?
1) Triazoles (Flucanazole & Voriconazole)
2) 5-Flucytosine
3) Echinocandins
Use of 5-Flucytosine?
Combination (+) Amphotericin B:
1) Candidiasis
2) Cryptococcosis (Meningitis & Pul Infections)
ADE of 5-Flucytosine
1) GI effects
2) Hepatotoxicity
3) Bone marrow supression
Use of Echinocandins
1) 1st line for invasive candidiasis
2) 2nd line for invasive asperigillosis
Which agents can be used for Asperigillosis?
1) Amphotericin B
2) Itraconazole (Intolerant to AB)
Which agents can be used for Invasive Asperigillosis?
1) Voriconazole (1st line)
2) Echinocandins
Which agents can be used for Invasive Candidiasis?
Echinocandins (1st line)
Which agent should not be given IV?
Nystatin (systemic toxicity)
Which drug should not be taken with antacids?
Itraconazole (low pH for better absorption)
Which agents can be used for Onychromycoses?
Itraconazole, Terbinafine
What is oral Terbinafine used for?
1) Onychromycoses (nail)
2) Tinea capitis (scalp)
What is Miconazole used for?
1) Tinea pedis
2) Tinea cruris
3) Tinea versicolor
4) Vulvovaginal candidiasis
What is Nystatin used for?
Commonly used for candida & oral cutaneous infections:
1) Oropharyngeal candidiasis (oral)
2) Vulvovaginal candidiasis (intra-vaginally)
3) Cutaneous candidiasis (topical)
4) GIT fungal infections
What is topical Terbinafine used for?
1) Tinea pedis
2) Tinea cruris
3) Tinea corporis (ringworm)
Safe for pregnancy
Amphotericin B
Terbinafine - Vaginal (A), Oral (B)