Anti Epileptics Flashcards

1
Q

Phenytoin

A
Na channel blocker 
Use GTCS and focal seizure 
S/e - HOTMALIKA 
Hirsuitism , osteomalacia , teratogenic , megaloblastic anemia , arrhythmia , lymph node enlargement , decrease vit K and Insulin , 
ataxia
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2
Q

Carbamazepine

A
Na channel blocker 
  C/I absence and myoclonus seizure 
DOC for trigeminal neuralgia 
                 Focal seizure 
DI 
Bipolar disorder 
S/E 4 a 
auto induction 
aplastic anemia 
adh release 
ataxia
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3
Q

Na channel blockers

A
Phenytoin 
carbamazepine
Ox Zonisamaide carbamazepine
 Topiramate 
Zonisamaide
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4
Q

Topiramate

A
Uses anti epileptic COMB
            Decrease craving of alcohol 
              Obesity 
              Migraine prophylaxis 
              Bipolar disorder
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5
Q

Pregabalin

Gabapentine

A

Increase gaba
DOC neuropathic pain
Diabetic neuropathy
Post herpetic leisions

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6
Q

Vigabatrin

A

Increase GABA
Gaba Transaminase inhibitor
S/E infantile spasm

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7
Q

Tiagabine

A

Transport or repuptake inhibitor of gaba

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8
Q

Drugs that increase GABA

A
Pregabaline 
Gabapentine 
Vigabatrin 
Tiagabine 
Barbiturate 
Benzodiazepines
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9
Q

Decrease glutamate drugs

A
Felbamate  - BM suppression 
Perampanel - in focal seizure
Ketamine - dissociative anaesthesia 
Memantine - alzimers disease
Riluzole
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10
Q

Ethosuximide

A

T CA+2 channel blocker

Use only in absence seizure

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11
Q

Retigabine

A

K+ channel opener
In focal seizure
Do not act on GABA

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12
Q

Sodium valproate

A

Na channel blocker
K channel blocker
Increase gaba
Decrease glutamate

DOC GTCS , absence ,focal , myoclonic atomic , Lennox gustaut

Bipolar disorder

S/E VALPROATE
Vomitting ,alopecia , liver toxicity, pancreatitis ,obesity , rash ,ataxia , teratogenicity ( max teratogenic anti epileptic)

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13
Q

Lamotregine

A

Na channel blocker
DOC a focal seizure

S/E Steven Johnson syndromes
Toxic epidermal necrolysis

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14
Q

Lemitiracetam

Brivaracetam

A

SV2A

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15
Q

Caanabidiol

A

Bind to Cb1

Dravit supyndrom

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16
Q

Stiripentol

A

Increase GABA

Inhibit LDH