Anti Epileptics Flashcards
Phenytoin
Na channel blocker Use GTCS and focal seizure S/e - HOTMALIKA Hirsuitism , osteomalacia , teratogenic , megaloblastic anemia , arrhythmia , lymph node enlargement , decrease vit K and Insulin , ataxia
Carbamazepine
Na channel blocker
C/I absence and myoclonus seizure
DOC for trigeminal neuralgia
Focal seizure
DI
Bipolar disorder
S/E 4 a
auto induction
aplastic anemia
adh release
ataxiaNa channel blockers
Phenytoin carbamazepine Ox Zonisamaide carbamazepine Topiramate Zonisamaide
Topiramate
Uses anti epileptic COMB
Decrease craving of alcohol
Obesity
Migraine prophylaxis
Bipolar disorderPregabalin
Gabapentine
Increase gaba
DOC neuropathic pain
Diabetic neuropathy
Post herpetic leisions
Vigabatrin
Increase GABA
Gaba Transaminase inhibitor
S/E infantile spasm
Tiagabine
Transport or repuptake inhibitor of gaba
Drugs that increase GABA
Pregabaline Gabapentine Vigabatrin Tiagabine Barbiturate Benzodiazepines
Decrease glutamate drugs
Felbamate - BM suppression Perampanel - in focal seizure Ketamine - dissociative anaesthesia Memantine - alzimers disease Riluzole
Ethosuximide
T CA+2 channel blocker
Use only in absence seizure
Retigabine
K+ channel opener
In focal seizure
Do not act on GABA
Sodium valproate
Na channel blocker
K channel blocker
Increase gaba
Decrease glutamate
DOC GTCS , absence ,focal , myoclonic atomic , Lennox gustaut
Bipolar disorder
S/E VALPROATE
Vomitting ,alopecia , liver toxicity, pancreatitis ,obesity , rash ,ataxia , teratogenicity ( max teratogenic anti epileptic)
Lamotregine
Na channel blocker
DOC a focal seizure
S/E Steven Johnson syndromes
Toxic epidermal necrolysis
Lemitiracetam
Brivaracetam
SV2A
Caanabidiol
Bind to Cb1
Dravit supyndrom
