Anti Epileptics

Question 1

MOA OF VALPROATE

Answer 1

Inhibits sodium channel and increases GABA

Question 2

First line drug for seizure

Answer 2

Valproate

Question 3

Side effects of valproate ( ALPRO)

Answer 3

Anemia
Hepatotoxicity
Pancreatitis
Spina bifida

Question 4

Moa of phenytoin

Answer 4

Inhibits sodium channel

Question 5

Side effects of phenytoin

Answer 5

Gingival hyperplasia
Fetal hydantoin syndrome
P450 inducers

Question 6

Order of kinetics of phenytoin

Answer 6

Zero order kinetics

Question 7

Moa of ethosuximide

Answer 7

Block t caclicum channels

Question 8

Use of ethosuxmide

Answer 8

Used in absence seizures

Question 9

Side effect of ethosuxmide

Answer 9

SJS

Question 10

Moa of carbamazepine

Answer 10

Increased refractory period of voltage gated sodium channel

Question 11

Use of cabamezapine

Answer 11

Used in trigeminal neuralgia

Question 12

Side effect of carbamazepine

Answer 12

SJS

Question 13

Moa of lamotrigine

Answer 13

Inhibits voltage gated sodium channel and acts on glutamate receptors

Question 14

Side effects of lamotrigine

Answer 14

SJS

Question 15

Moa of benzodiazepines

Answer 15

Increase frequency of chloride channels

Question 16

Moa of barbiturates

Answer 16

Increase duration of opening of chloride channels

Question 17

Moa of tiagabine and vigabatrin

Answer 17

They have activity at GABA

Question 18

Moa of topiramate

Answer 18

Inhibits voltage gated sodium channels