Anti-Epileptic Medication

Question 1

Enhances inactivation of voltage-gated sodium channels

Answer 1

MOA for Carbamazepine (Tegretol)

Question 2

Direct gaba agonist and potentiates the effects of GABA via Modulation of chloride efflux

Answer 2

MOA for Clonazepam (Klonopin)

Question 3

Inhibition of T-type calcium channels

Answer 3

MOA for Ethosuximide (Zarontin)

Question 4

Binds to GABA-A Receptor and potentiates GABA via modulation of chloride efflux

Answer 4

MOA for Phenobarbital

Question 5

Prodrug of PHENOBARBITAL
Converted to active intermediary metabolite phenylethyl malo-n-amide

Answer 5

MOA for Primidone

Question 6

Enhances inactivation of voltage-gated ion channels

Answer 6

MOA for Phenytoin

Question 7

Enhances inactivation of voltage-gated ion channels. Phosphorylated pro-drug of phenytoin, activated by serum esterases

Answer 7

MOA for Fosphenytoin (Cerebyx)

Question 8

Hypothesized to mediate GABA transmission

Answer 8

MOA for Valproic Acid

Question 9

Binds to alpha-2 subunit of calcium channel, with unknown effects on seizures

Answer 9

MOA for Gabapentin

Question 10

Enhances fast inactivation of voltage-gated sodium channels

Answer 10

MOA for Lamotrigine

Question 11

inhibits synaptic vesicle SV2A which prevents neurotransmitter (gaba/glutamate) release

Answer 11

MOA for Levetiracetam (Keppra)

Question 12

Enhances inactivation of voltage-gated sodium channels

Answer 12

MOA for Ocarbazepine

Question 13

Mediates voltage-gated ion channels

Answer 13

MOA for Lacosamide

Question 14

Non-competitive antagonist of glutamate receptors on postsynaptic neurons (Slows down excitement)

Answer 14

MOA for Perampanel

Question 15

Binds GABA-A receptors and potentiates GABA via modulation of chloride conductance

Answer 15

MOA for Clobazam