Anti-Epileptic Drugs

Question 1

Lamotrigine

MOA/SE/Interactions

Answer 1

inhibit glutamate and VG Na channels/
SJS, arrhythmias/
estrogen, VPA, uses CYP450

Question 2

Carbamazepine

MOA/SE/Interactions

Answer 2

extends VG Na channels/
N/V, dizziness, ataxia/
CYP450 inducer/user

Question 3

Lacosamide

MOA/SE/Interactions

Answer 3

enhances slow activation of VG Na/
vertigo, ataxia, PR prolongation/
none

Question 4

Phenytoin

MOA/SE/Interactions

Answer 4

blocks VG Na channels/
gingival hypertrophy, dec bone density, dec folate, ataxia, neuropathy, purple glove syndrome/
CYP450 inducer

Question 5

Zonisamide

MOA/SE/Interactions

Answer 5

blocks T-type Ca channels, CAi/
somnolence, confusion, dizzy/
none

Question 6

Gabapentin

MOA/SE/Interactions

Answer 6

GABAergic/
somnolence, edema/
none

Question 7

Vigabatrin

MOA/SE/Interactions/Use

Answer 7

inhibits GABA transaminase/
vision loss, tremor, URI/
none/
infantile spasms

Question 8

Valproate

MOA/SE/Interactions

Answer 8

increases GABA/
alopeca, GI issues, high ammonia, thrombocytopenia/
CYP user

Question 9

Ethosuxamide

MOA/SE/Interactions/Use

Answer 9

blocks T-type calcium channels/
weight loss, SJS, GI issues/
CYP user/
Absence seizures

Question 10

Levetiracetam

MOA/SE/Interactions

Answer 10

binds to SV2A (N-type Ca)/
somnolence/
none

Question 11

Parampanel

MOA/SE/Interactions/Use

Answer 11

AMPA antagonist/
weight gain, psych reactions/
CYP user/
partial onset seizures