Anti-emetics Flashcards
What is the most common complication observed in PACU?
PONV
also most common reason (along with pain) for hospitalization following ambulatory surgery
What are the pathways in which antiemetics can prevent and treat PONV?
centrally acting
peripherally acting
combination therapies
What do at risk patients benefit from?
one or more prophylactic measures
What are the types of risk factors for PONV?
surgical, anesthetic, and individual
What are the patient risk factors for PONV?
Female gender (overall strongest predictor), history of PONV or motion sickness, non-smoker, age (risk decreases by 10% per decade), apprehension (r/t swallowed air and abdominal distension), gastroparesis, recent food ingestion
What are the surgical risk factors for PONV?
increased duration of anesthetic/surgery (each 30 min increase in duration increases PONV risk by 60%) surgical type (laparoscopy, ENT, T&A, breast, GU/GYN)
What are the anesthesia risk factors for PONV?
preop administered opioid analgesics, inhalational induction, volatile anesthetic agents, nitrous oxide
What induction agent is found to result in less postoperative vomiting?
Propofol
What are the post-anesthetic related risk factors for PONV?
ambulation, postural hypotension, uncontrolled pain, postoperative opioid administration, early PO intake, lower FiO2 concentration, reversal agents (specifically neostigmine)
According to the SAMBA guidelines when would we give prophylaxis?
Moderate risk- give one or two prophylactic measures
High risk- multiple interventions
The risk factors included in the Apfel score are:
female gender, nonsmoker, history of PONV, postoperative opioids
How can vomiting be triggered directly?
noxious stimuli, toxins, drugs, irritants
How can vomiting be triggered indirectly?
stimulation of the vomiting center in the medulla oblongata
What makes up the vomiting center in the brain?
located in the medulla oblongata: cerebral cortex/thalamus, vestibular apparatus, vagal afferent GI tracts, chemoreceptor trigger zone*** important part of the pathway
What is the goal of combination therapy?
targets multiple receptors, provides rapid onset agent and longer duration of action, benefits patients at high risk, treat with different pharmacological agent class if prophylactic treatment did not work consider combo therapy for certain surgical procedures: gastric, esophageal, plastics, eye, mandibular jaw wiring, increased ICP
What are the receptors involved in the vomiting pathway?
histamine, muscarinic, opioid, dopamine (D2), 5-hydroxytryptamine (serotonin)
What specific serotonin receptor mediates vomiting?
5-HT3 receptor mediates vomiting and is found in GI tract and brain (CTZ & NTS)
How are the effects of 5-HT3 receptor mediated?
via ion channel receptors (gated Na+/K+ channels)
What is the trigger zone of serotonin activated by?
anesthetics and opioids
What does serotonin do to the respiratory system?
causes increased airway resistance
What does serotonin do to the GI system?
release of Ach increases peristalsis
What does serotonin do to the CV system?
powerful vasoconstrictor (except in the heart/skeletal muscle), vasodilation in the heart
What are the serotonin receptor antagonists and what is their action?
ondansetron, palonosetron, dolasetron
inhibit central and peripheral stimulation of 5-HT3 receptors
What are the side effects of serotonin receptor antagonists?
headache, prolonged QT interval
When are serotonin receptor antagonists?
administered at the end of surgery
What are benefits of serotonin receptor antagonists?
they do not cause sedation and are generally well tolerated
What is the typical dosage of ondansetron?
PO: 4 or 8 mg or for PONV prophylaxis 16 mg PO dose x 1 one hour before induction of anesthesia
4 mg single dose IV or 0.1 mg/kg if <40 kg
What is the half-life and onset of ondansetron?
half-life: 4 hours
onset: 30 minutes
peak plasma is almost immediate
Where is zofran metabolized?
liver by hydroxylation and conjugation CYP-450
severe hepatic impairment will decrease clearance so dose adjustment needed
no dose adjustment for kidneys
Side effects for ondansetron include:
headache, dizziness, diarrhea, constipation, QTc prolongation
When is ondansetron most effective?
when administered at the end of the surgical procedure
What anti-emetic is effective for chemotherapy induced N/V?
palonosetron
What is the half-life of palonosetron?
40 hours
Palonosetron should not be given to
pediatric patients
The dosing of palonosetron is
0.75 mg
no dosage adjustments needed for elderly, renal, hepatic patients
What is the mechanism of action of dolasetron?
reduce activity of the vagus nerve to limit activation of the vomiting center in the medulla oblongata
What is the dosage of dolasetron?
12.5 mg IV
What is the duration of action of dolasetron?
4-9 hours
How is dolasetron eliminated?
liver via CYP450 and the kidneys
What is the onset of action of dolasetron?
immediate- very fast acting
When should dolasetron (anzemet) be administered?
within 15 minutes before the end of anesthesia
What dosage of dolasetron is given?
PO dose 100 mg 1-2 hours preop or 50 mg IV
What are the adverse effects of dolasetron?
headache, dizziness, constipation, QT prolongation
How is dolasetron excreted?
in the urine/feces
Which serotonin antagonist has an active metabolite and what is it?
dolasetron
active metabolite: hydrodolasetron
What is the mechanism of action of droperiol?
blocks dopamine receptors that contribute to development of PONV
What properties does droperiol possess?
anxiolytic, sedative, hypnotic and antiemetic properites
What class is droperiol a part of?
butyrophenone/dopamine receptor antagonist