Anti-emetic - Metoclopramide Flashcards
1
Q
What is metoclopramide used for?
A
1) prophylaxis and treatment of nausea and vomiting
especially with reduced gut motility
2
Q
How does metoclopramide work?
A
Metoclopramide blocks the dopamine2 receptors in the chemoreceptor zone (brain) and the GI tract.
This leads to:
- increased gastric emptying
- less stimulation of the medulla’s “vomiting centre”
3
Q
what are the side effects of metoclopramide?
A
- diarrhoea
- ## movement abnormalities
4
Q
What are the contraindications of metoclopramide?
A
- avoid use in children and young adults as movement abnormalities more common.
- GI obstruction due to risk of perforation as drug has prokinetic effect
5
Q
What are the drug interactions of metoclopramide?
A
- Antipsychotic (movement abnormalities increased when combined)
- dopaminergic agents of parkinsons (these drugs work against each other)
6
Q
what is the starting dose for metoclopramide?
A
10mg up to three times daily PO / IM / IV
7
Q
When can metoclopramide be considered for GORD?
A
In GORD treatment when PPIs and H2 blockers aren’t enough then add metoclopramide. It helps increase rate of gastric emptying.
