Anti-diabetic Agents Flashcards
What type of insulin preparation is represented by the blue line?
Rapid acting (Lispro, Aspart, Glulisine, Inhaled)
What type of insulin preparation is represented by the black line?
Short acting (Regular)
What type of insulin preparation is represented by the red line?
Intermediate (NPH)
What type of insulin preparation is represented by the pink and dark blue lines?
Long acting (Insulin detemir, Insulin glargine)
What is the classic triad of symptoms associated with DM?
Polyuria, polyphagia, polydipsia
Inability of the body to use glucose as an energy source leads to hyperlipidemia which causes what 2 associated conditions commonly seen with DM?
Atherosclerosis (of large and medium sized arteries) and HTN (with progressive renal involvement)
Aside from the classic triad, and atherosclerosis and HTN, what are other common sxs seen with DM? (4)
Peripheral neuropathy, acanthosis nigricans, myoglobinuria (increased muscle breakdown), microangopathy (unknown cause)
T1DM is characterized by virtually absent circulating insulin resulting in the need for exogenous insulin to be injected. What is the cause for this?
Pancreatic beta cells fail to respond to insulinogenic stimuli (glucose)
What is typically the trigger of sustained beta cell stimulation leading to hyperinsulinism and receptor insensitivity in T2DM?
Chronic over feeding
What may interrupt the disease cycle of T2DM?
Reduction of over feeding
Why is T2DM considered a progressive disease?
Start losing pancreas’ ability to produce insuline (T2DM → T1DM)
How does treatment progress as T2DM progresses?
Monotherapy → combo therapy → insulin
What are the 4 diagnosis methods for DM?
- DM sxs and random blood glucose (≥ 200mg/dL)
- Fasting blood glucose (≥ 126 mg/dL)
- Oral glucose challenge (blood glucose ≥ 200 @ 2 hrs)
- HbA1C ≥ 6.5%
Although an HbA1C level of ≥ 6.5% is diagnositc for DM, what is considered poorly controlled DM?
> 10%
You typically want a DM pt to have an HbA1C of < 6 BUT under what condition?
If you can safely get them to that level without hypoglycemic events
How is glycosylation affected as glucose levels increase?
Increases (A1C = glycosylated protein)
Preproinsulin → insulin yields what?
Insulin + C-peptide
(C-peptide provides long term marker for measuring insulin)
Release of insulin is activated by what?
Glucose, beta2 adrenergic agonist
Insulin promotes entry of glucose into what tissues? (2)
Skeletal muscle and fat tissue
Insulin is NOT required for glucose transport into what tissues? (2)
Brain and liver
Insulin release is stimulated by beta2 adrenergic agonists but inhibited by what?
Alpha2 agonists
How is insulin released from beta cells? (6 steps)
- Glucose transported via GLUT2
- Metabolism
- Increased ATP
- K+ channel closes and cell depolarizes
- Ca2+ channels open and Ca2+ enters cell
- Insulin released from cell via exocytosis
The following actions of insulin are considered what?
Decreased gluconeogensis and increased glycogen synthesis in the liver, and glucose uptake in muscle and adipose tissue
Anabolic actions (because insulin inhibtits catabolic actions)
Where do GLUT1 and GLUT3 act?
Brain
Where does GLUT2 act?
Beta cells of pancreas
Where does GLUT4 act?
Muscle and adipose
The affinity for glucose is greatest/ least in which GLUT transporters?
GLUT2 < GLUT4 < GLUT1/ GLUT3
How is uptake of glucose unique with respect to the GLUT4 transporter?
Insulin-mediated (aka insulin dependent)
Overproduction or underutilization of glucose can cause what imbalance?
Lactic acidosis
Which drugs are approved for treatment of T2DM in pts who also have ASCVD? (3)
Liraglutide, Canaglifozin, Empagliflozin
What is typically considered 1st line treatment for DM?
Lifestyle modification (important in treatment and CV health)
What contributes to > 2/3 of all morbidity/ mortality/ costs of patients with DM?
CV disease
What has shown to be more important in treatment of patients with CV disease + DM?
Control of BP/ cholesterol levels > tightly controlled blood glucose levels
What 3 things must be treated simultaneously in patients with DM and CV disease?
A1C, BP, cholesterol
(bottom line = start intensive therapy immediately for best effect on CV health, but individuaize treatment and avoid hypoglycemia)
If a pt has a history of poor glycemic control, what might this indicate about intensive glycemic control?
No CV benefit
What is the MOA of insulin?
Stimulates GLUT4 (insulin mediated) uptake of glucose into muscle and adipose tissues
The goal of what DM treatment is to mimic what the body does (both meal-stimulated insulin and basal insulin)
Injections
(create insulin profile and eat to fill it)
Regular + intermediate insulin mix injection is given when?
1 hour before breakfast and dinner
Rapid-acting + long-acting insulin injections are given when?
Rpaid acting injected 1 hour before meals, long acting injected before bedtime
What DM treatment involves basal levels of rapid acting insulin maintained throughout the day but increased right before meal based on meal components (pt stimulated bolus)
Insulin pumps
What are the most common sxs of hypoglycemia? (4)
Tachycardia, confusion, vertigo, sweating
(dangerous b/c SEs will disappear w repeated events)
Besides hypoglycemia, what is a common side effect of insulin treatment for DM?
Weight gain (increased lipolysis)
What is the treatment for hypoglycemia? (2)
Give 50-100mL of 50% glucose solution IV, 0.5- 1mg glucagon injection
Which 2 types of insulin are given IV?
Rapid-acting and short-acting
Which 2 types of insulin are NOT given IV?
Intermediate-acting and long-acting (basal)
Why is rapid-acting insulin preferred over regular insulin (short-acting)?
Less hypoglycemia
What type of insulin is Insulin lispro (Humalog)?
Rapid-acting
What type of insulin is Insulin aspart (NovoLog)?
Rapid-acting
What type of insulin is Insulin glulisine (Apidra)?
Rapid-acting
What type of insulin is Insulin, inhaled (Afrezza) and what is a SE of it?
Rapid-acting, SE: cough
What are the short-acting insulins?
Regular insulin (Novolin R, Humulin R)
What are the intermediate acting insulins?
NPH insulin (Humulin N, Novolin N)
What type of insulin is Insulin glargine (Lantus)?
Long-acting (basal)
What type of insulin is Insulin detemir (Levemir)?
Long-acting (basal)
What type of insulin is Insulin degludec (Tresiba)?
Long-acting (basal)
What is 1st line treatment for T2DM when A1C is > 10%?
Long-acting (basal)
(Insulin glargine (Lantus), Insulin detemir (Levemir), Insulin degludec (Tresiba))
What hormone antagonizes insulin?
Glucagon
What are the 3 routes of administration for glucagon?
SC, IM, IV (but gradual onset)
What is the MOA for glucagon?
Increase blood glucose levels by mobilizing hepatic glycogen (when glycogen stores available)
What are the indications for use of glucagon? (2)
Beta blocker overdose, radiology
(potent inotropic and chronotropic effects on heart via 2nd messenger, relaxation of intestine)