Anti Cancer Drugs

Question 1

Busulfan S/e

Answer 1

5b’s
Bm supression ( max risk)
Brain (sz)
Breaking tumour( tumour lysis)
Budd chiari
Bur bur in lungs ( fibrosis)

Question 2

Mesna full form and route

Answer 2

IV Mercapto ethane sulfonate sodium

Question 3

Ototoxic drugs

Answer 3

Aminoglycosised
Cyclophosphamide

Question 4

What is chloroacetaldehyde

Answer 4

Active form of ifosfamide producing neurotoxicity

Question 5

Nitrosoureas fun

Answer 5

Resistant gliomas

Question 6

Blocks CXCR4 and used for stemcell extraction

Answer 6

PLERIXAFOR

Question 7

Bone marrow cell transplantation drugs

Answer 7

B busalfan
M melfalan
C cyclophosphamide
T thiotepa

Question 8

Cisplatin causes which RTA

Answer 8

type 2

Question 9

Nephroprotector in cisplatin poisoning

Answer 9

Amifostine

Question 10

Myeloprofierative disorders RX

Answer 10

Hydroxyurea——-> Anagrelide——-> Ruxolitinib (JAK Kinase inhibitor)

Question 11

Voxelotor

Answer 11

Venoocclusive crisis Rx
It increases the hb affinity for o2

Question 12

P selectin inhibitor used in sickle cell disease

Answer 12

Crinzanlizumab

Question 13

Sickle cell disease treatment

Answer 13

Hydroxyurea
Glutamic acid
Crinzalizumab
Voxelotor

Question 14

Folate analogues mechanism of action

Answer 14

Inhibition of
DHFR enzyme
Thymidylate synthase
Purine and pyrimidine synthesis

Question 15

Pemetrexed

Answer 15

Hint : pe me ( pleural membrane tumour )
DOC of mesothelioma

Question 16

Pralatrexate

Answer 16

Hint : PERIPHERAL ( PRALA)
T CELL ( TRE)
Cutaneous T cell lymphoma

Question 17

The mtx analogue used in pneumocystis infection is

Answer 17

Trimetrexate

Question 18

What is glucarpidase

Answer 18

Mtx toxicity treatment

Question 19

Refractory CML drug

Answer 19

Omecetaxine