anti-arrthymatics

Question 1

IA classification of drug

Answer 1

Example = Procainamide
MOA = Na+ channel blocker, slow phase 0 depolarisation
ERP = increase
Clinical uses = Refractory ventricular tachycardias that tend to progress to VF

Question 2

IB classification of drug

Answer 2

Example = Lidocaine
MOA = Na+ channel blocker, shortens phase 3 repolarisation and actional potential duration
ERP = Unchanged
Clinical uses = Refractory ventricular tachycardias that tend to progress to VF

Question 3

IC classification of drug

Answer 3

Example = Flecainide
MOA = Na+ channel blocker, slows phase 0 depolarisation
ERP = Unchanged
Clinical uses = Refractory ventricular tachycardias that tend to progress to VF

Question 4

II classification of drug

Answer 4

Example = Metoprolol, propranolol
MOA = Beta-adrenoceptor blocker, suppresses phase 4 depolarisation
ERP = unchanged

Clinical uses
: tachycardia caused by sympathetic activation
: atrial fibrillation
: AV nodal reentrant tachycardia
: decrease sudden arrhythmic death post-MI

Question 5

III classification of drug

Answer 5

Example = Amiodarone, sotalol, bretylium
MOA = K+ channel blocker, prolongs phase 3 repolarisation
ERP = Increase

Clinical uses
: maintaining normal sinus rhythm in patients with atrial fibrillation
: prevention of reentrant ventricular tachycardia

Question 6

IV classification of drug

Answer 6

Example = Verapamil, diltiazem
MOA = Ca2+ channel blocker, prolongs action potential
ERP = Increase
Clinical uses = Supraventricular tachycardia, hypertension, angina