Anti-Arrhythmic Flashcards
1
Q
Quinidine Class/MoA
A
- class 1A
- blocks Na+ –> slow conduction velocity, prolonged refraction
- highly protein bound
2
Q
Quinidine D-D interactions
A
- 2D6 inhibitor drugs (digoxin, warfarin, BBs)
- QT prolonging drugs such as digoxin
3
Q
Quinidine AEs
A
- diarrhea
- lightheadedness
- thrombocytopenia, hepatitis, QT-prolongation
- torsades, Vtach
4
Q
Procainamide class/MoA
A
- class 1A
- blocks Na+ –> slow conduction velocity, prolonged refraction
- IV, activated in liver
5
Q
Procainamide drug interactions
A
- CYP2D6 substrate
- QT prolonging drugs
6
Q
Procainamide AEs
A
- hypotension
- torsades de pointes
- nausea
- coagulation disorders
7
Q
Disopyramide class and MoA
A
- class 1A
- sodium blockade –> slow conduction velocity, prolonged refraction
8
Q
Disopyramide drug interactions & AEs
A
- QT-prolonging drugs
- AEs: decreases contractility, xerostomia, constipation, urinary hesitancy
9
Q
Lidocaine class/MoA
A
- class 1B
- accelerates repolarization
10
Q
Lidocaine uses
A
- treats ventricular arrhythmias associated with MI
- local anesthesia
chronic pain
11
Q
Lidocaine AEs
A
- dizziness, drowsiness, N/V, blurred vision, hallucinations
- seizures, bradycardia, respiratory depression
12
Q
Flecanide class/MoA
A
- Class 1C
- blocks Na+
- profoundly slows conduction velocity without altering refraction
13
Q
Flecanide AEs/interactions
A
- AEs: dizziness, blurred vision, dyspnea, pro-arrhythmia, HF exacerbation
- interacts w/ CYP2D6 substrate
14
Q
Propafenone class/MoA
A
- class 1C
- sodium blockade
- profoundly slows conduction velocity without altering refraction
15
Q
Propafenone AEs
A
- new or worsening arrhythmia, VTach, bradycardia, HF exacerbation, CNS effects
16
Q
Propafenone D-D interactions
A
- avoid with other anti arrhythmics and QT prolonging drugs
- CYP2D6 substrate/inhibitor (digoxin, warfarin, BB, etc)
17
Q
Amiodarone class/MoA
A
- class III agent
- K, Ca, Na blockades
- slowed HR, AV conduction, QT prolongation
18
Q
Amiodarone Uses
A
- treats/prevents V-Fib and V-Tach
- prevention of atrial tachycardia
19
Q
Amiodarone AEs
A
- optic neuritis
- photosensitivity, blue slate skin discoloration
- hypothyroidism, GI issues
- corneal micro deposits
20
Q
Amiodarone BBWs
A
- pt should be in hospital when initiating
- pro-arrhythmic (bradycardia)
- hypotension
21
Q
monitor when using amiodarone
A
- Liver function tests
- thyroid function tests
- pulmonary function tests
22
Q
Ibutilide class/MoA
A
- Class III
- K, Ca, and Na channel blockade –> slowed HR/AV conduction; QT prolongation
23
Q
Ibutilide AEs/D-D interactions
A
- AEs: arrhythmias, hypotension (monitor EKG for at least 4 hrs after admin)
- do not use with other QT prolonging drugs
24
Q
Sotalol class/MoA
A
- class III
- K, Ca, and Na channel blockade –> slowed HR/AV conduction; QT prolongation
- non selective BB
25
Sotalol AEs/D-D interactions
- AEs: bradycardia, hypotension, QT prolongation
- do not use with other QT prolonging drugs or those that decrease HR
26
Dofetilide Class and MoA
- class III
- K, Ca, and Na channel blockade --> slowed HR/AV
27
Dofetilide AEs/D-D interactions
- AEs: torsades and other arrhythmias
- do not use with other QT prolonging drugs
28
Drugs for rate control in atrial fibrillation
- Beta blockers
- Ca channel blockers
- Digoxin (must be in combo w/ another drug)
29
Drugs for rhythm control in atrial fibrillation
Class 1C: flecainide & propafenone
Class III: amiodarone, dofetilide, ibutilide
30
Drugs for ventricular arrhythmias
- Lidocaine
- Procainamide
- Amiodarone
